In the body, cells inhabit within a complex three-dimensional (3D) extracellular matrix that
provides physical and chemical signals to regulate the cell fate. Cultured cells in Petri dishes …

Cardiovascular disease is a leading cause of death worldwide, necessitating the
development of effective treatment strategies. A myocardial infarction involves the blockage …

Tissue engineers and stem cell biologists have made exciting progress toward creating
simplified models of human heart muscles or aligned monolayers to help bridge a …

Understanding the phenotypic development of human induced pluripotent stem cell-derived
cardiomyocytes (hiPSC-CMs) is a prerequisite to advancing regenerative cardiac therapy …

Background Human-induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have
shed great light on cardiac regenerative medicine and specifically myocardial repair in heart …

Textured surfaces with periodic topographical features and long-range order are highly
attractive for directing cell-material interactions. They mimic physiological environments …

Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) generally have an
immature fetal-like phenotype when directly compared to isolated CMs from human hearts …

Hypertrophic cardiomyopathy (HCM) is a leading cause of sudden cardiac death that often
goes undetected in the general population. HCM is also prevalent in patients with cardio …

Traditional lithography plays a significant role in the fabrication of micro-and nanostructures.
Nevertheless, the fabrication process still suffers from the limitations of manufacturing …

The composite material-like extracellular matrix (ECM) in the sinoatrial node (SAN) supports
the native pacemaking cardiomyocytes (PCMs). To test the roles of SAN ECM in the PCM …