In the last few decades, proliferative markers have been broadly evaluated as prognostic
and predictive factors for early stage breast cancer patients. Several papers evaluating one …

Progression through the cell cycle is governed by cyclin-dependent kinases (cdks), whose
activity is inhibited by the cdk inhibitors. Cyclins, cdks, and cdk inhibitors are frequently …

Wnt-1 was first identified as a protooncogene activated by viral insertion in mouse mammary
tumors. Transgenic expression of this gene using a mouse mammary tumor virus LTR …

Estrogens and antiestrogens influence the G1 phase of the cell cycle. In MCF-7 breast
cancer cells, estrogen stimulated cell cycle progression through loss of the kinase inhibitor …

Expression of cell-cycle modulators at the G 1-S boundary, retinoblastoma gene product
(pRb), p21, p16, p27, p53, cyclin D 1, and cyclin E was investigated with 104 hepatocellular …

High expression of the epidermal growth factor receptor (EGFR) has been implicated in the
development of squamous‐cell carcinomas of head and neck (SCCHN). ZD1839 ('Iressa') is …

Abstract p21 Waf1/Cip1, the cyclin-dependent kinase (CDK) inhibitor belonging to the
KIP/CIP family, was initially regarded as a tumor suppressor protein because it was …

Abstract BACKGROUND p21 (waf1/cip1) protein is a cyclin‐dependent kinase inhibitor able
to arrest the cell cycle at the G1 phase by inhibiting DNA replication. The expression of p21 …

We previously showed the anticancer effect of crocin, a saffron carotenoid, in both breast
and gastric cancers in animal models, but its mechanism of action is not clearly known, yet …

BACKGROUND A number of conventional histopathologic features have been associated
with recurrence of ductal carcinoma in situ (DCIS) after surgery alone and are included in …