Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …

NAD+ was discovered during yeast fermentation, and since its discovery, its important roles
in redox metabolism, aging, and longevity, the immune system and DNA repair have been …

Vitamin B3 (nicotinic acid, niacin) deficiency causes the systemic disease pellagra, which
leads to dermatitis, diarrhea, dementia, and possibly death depending on its severity and …

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease or Charcot
disease, is a fatal neurodegenerative disease that affects motor neurons (MNs) and leads to …

Neurodegenerative disorders pose a significant health burden and imprint a debilitative
impact on the quality of life. Importantly, aging is intricately intertwined with the progression …

Human longevity has increased dramatically during the past century. More than 20% of the 9
billion population of the world will exceed the age of 60 in 2050. Since the last three …

Altered energy metabolism has been implicated both in aging and the pathogenesis of late-
onset Alzheimer's disease (LOAD). However, it is unclear which anomalies are acquired …

Endogenous tryptophan metabolism pathways lead to the production of serotonin (5‐
hydroxytryptamine; 5‐HT), kynurenine, and several downstream metabolites which are …

Abstract pH-responsive emulsion stabilizer can be used as an ideal Pickering emulsion type
drug embedding and sustained release. However, achieving an optimal balance of particle …

Nicotinamide (vitamin B3) is a key component in the cellular production of Nicotinamide
Adenine Dinucleotide (NAD) and has long been associated with neuronal development …