Natural killer cells in antitumour adoptive cell immunotherapy

TJ Laskowski, A Biederstädt, K Rezvani - Nature Reviews Cancer, 2022 - nature.com
Natural killer (NK) cells comprise a unique population of innate lymphoid cells endowed with
intrinsic abilities to identify and eliminate virally infected cells and tumour cells. Possessing …

NK cell-based cancer immunotherapy: from basic biology to clinical development

S Liu, V Galat, Y Galat4, YKA Lee… - Journal of hematology & …, 2021 - Springer
Natural killer (NK) cell is a specialized immune effector cell type that plays a critical role in
immune activation against abnormal cells. Different from events required for T cell activation …

CAR-NK cells: A promising cellular immunotherapy for cancer

G Xie, H Dong, Y Liang, JD Ham, R Rizwan, J Chen - EBioMedicine, 2020 - thelancet.com
Natural Killer (NK) cells and CD8+ cytotoxic T cells are two types of immune cells that can
kill target cells through similar cytotoxic mechanisms. With the remarkable success of …

NK cells for cancer immunotherapy

N Shimasaki, A Jain, D Campana - Nature reviews Drug discovery, 2020 - nature.com
Natural killer (NK) cells can swiftly kill multiple adjacent cells if these show surface markers
associated with oncogenic transformation. This property, which is unique among immune …

'Off-the-shelf'allogeneic CAR T cells: development and challenges

S Depil, P Duchateau, SA Grupp, G Mufti… - Nature reviews Drug …, 2020 - nature.com
Autologous chimeric antigen receptor (CAR) T cells have changed the therapeutic
landscape in haematological malignancies. Nevertheless, the use of allogeneic CAR T cells …

CAR-NK cells for cancer immunotherapy: from bench to bedside

L Zhang, Y Meng, X Feng, Z Han - Biomarker Research, 2022 - Springer
Natural killer (NK) cells are unique innate immune cells and manifest rapid and potent
cytotoxicity for cancer immunotherapy and pathogen removal without the requirement of …

CAR T cells for solid tumors: new strategies for finding, infiltrating, and surviving in the tumor microenvironment

M Martinez, EK Moon - Frontiers in immunology, 2019 - frontiersin.org
Chimeric antigen receptor (CAR) T cells, T cells that have been genetically engineered to
express a receptor that recognizes a specific antigen, have given rise to breakthroughs in …

Natural killer cells in clinical development as non-engineered, engineered, and combination therapies

N Lamers-Kok, D Panella, AM Georgoudaki… - Journal of Hematology & …, 2022 - Springer
Natural killer (NK) cells are unique immune effectors able to kill cancer cells by direct
recognition of surface ligands, without prior sensitization. Allogeneic NK transfer is a highly …

[HTML][HTML] Chimeric antigen receptor T-cell therapy—assessment and management of toxicities

SS Neelapu, S Tummala, P Kebriaei… - Nature reviews Clinical …, 2018 - nature.com
Immunotherapy using T cells genetically engineered to express a chimeric antigen receptor
(CAR) is rapidly emerging as a promising new treatment for haematological and non …

CAR exosomes derived from effector CAR-T cells have potent antitumour effects and low toxicity

W Fu, C Lei, S Liu, Y Cui, C Wang, K Qian, T Li… - Nature …, 2019 - nature.com
Genetically engineered T cells expressing a chimeric antigen receptor (CAR) are rapidly
emerging a promising new treatment for haematological and non-haematological …