The ability to predict the evolutionary trajectories of antibiotic resistance would be of great
value in tailoring dosing regimens of antibiotics so as to maximize the duration of their …

Bacterial genomes are remarkably stable from one generation to the next but are plastic on
an evolutionary time scale, substantially shaped by horizontal gene transfer, genome …

Abstract Changes in gene copy number are among the most frequent mutational events in
all genomes and were among the mutations for which a physical basis was first known. Yet …

An important mechanism for generation of new genes is by duplication-divergence of
existing genes. Duplication-divergence includes several different submodels, such as …

Operons are a hallmark of the genomic and regulatory architecture of prokaryotes. However,
the mechanism by which two genes placed far apart gradually come close and form operons …

The rapid pace of genomic sequence analysis is increasing the awareness of intrinsically
dynamic genetic landscapes. Gene duplication and amplification (GDA) contribute to …

The isolation of aerobic citrate-utilizing Escherichia coli (Cit+) in long-term evolution
experiments (LTEE) has been termed a rare, innovative, presumptive speciation event. We …

Heteroresistance is a medically relevant phenotype where small antibiotic-resistant
subpopulations coexist within predominantly susceptible bacterial populations …

Polymyxins [colistin and polymyxin B (PMB)] comprise an important class of natural product
lipopeptide antibiotics used to treat multidrug-resistant Gram-negative bacterial infections …

Antibiotic resistance is a continuously increasing concern for public healthcare.
Understanding resistance mechanisms and their emergence is crucial for the development …