In the normal central nervous system, endothelin-1 (ET-1) is found in some types of neurons,
epithelial cells of the choroid plexus, and endothelial cells of microvessels, but it is usually …

Moving from early studies, we here review the most recent evidence linking metabotropic
glutamate (mGlu) receptors to processes of neurodegeneration/neuroprotection. The use of …

Dry eye disease (DED) is a common ocular disorder characterized by an inadequate
lubrication of the eye by tears leading to inflammation and the alteration of the ocular …

(1) Background: Over the past 10 years, a number of scientific studies have demonstrated
the therapeutic potential of cannabinoid compounds present in the Cannabis Sativa and …

Macamides are a distinct class of secondary metabolites, benzylamides of long chain fatty
acids, which were isolated from the Peruvian plant Lepidium meyenii (Maca). As structural …

Abstract Background and Purpose Therapeutic hypothermia (TH) has become the standard
care to reduce morbidity and mortality in neonates affected by moderate‐to‐severe hypoxic …

Abstract Bv8/prokineticin 2 (PK2) is a member of a bioactive family of peptides that regulate
multiple functions in the CNS including hyperalgesia, neurogenesis, neuronal survival and …

In ischemic stroke, there is only one approved drug, tissue plasminogen activator, to be used
in clinical conditions for thrombolysis. New neuroprotective therapies for ischemic stroke are …

Background and Purpose—MAGL (monoacylglycerol lipase) is an enzyme that hydrolyzes
the endocannabinoid 2-arachidonoylglycerol and regulates the production of arachidonic …

Abstract Arachidonyl-2-chloroethylamide (ACEA), a highly selective agonist of cannabinoid
receptor 1 (CB1R), has been reported to protect neurons in ischemic injury. We sought to …