This review provides insights on the impact of glycosylation in cancer biology and its
influence in the current approaches of targeted cancer therapies in the clinical setting. The …

Despite recent progress in understanding the cancer genome, there is still a relative delay in
understanding the full aspects of the glycome and glycoproteome of cancer. Glycobiology …

Decades of research have disclosed a plethora of alterations in protein glycosylation that
decisively impact in all stages of disease and ultimately contribute to more aggressive cell …

Aberrant glycosylation plays a fundamental role in key pathological steps of tumour
development and progression. Glycans have roles in cancer cell signalling, tumour cell …

Protein glycosylation and other post-translational modifications are involved in potentially all
aspects of human growth and development. Defective glycosylation has adverse effects on …

Tumour metastasis is the main cause of cancer related deaths. Metastasis is an intricate
multi-step process that requires the acquisition of several cancer cell features, including the …

A growing body of evidence supports crucial roles for glycans at various pathophysiological
steps of tumour progression. Glycans regulate tumour proliferation, invasion …

Aberrant glycosylation occurs in essen-tially all types of experimental and human cancers,
as has been observed for over 35 years, and many glycosyl epitopes constitute tumor …

Fucosylation is one of the most common modifications involving oligosaccharides on
glycoproteins or glycolipids. Fucosylation comprises the attachment of a fucose residue to N …

Glycosylation is one of the most common post‐translational modification reactions and
nearly half of all known proteins in eukaryotes are glycosylated. In fact, changes in …