Primary aldosteronism (PA) is the most common form of secondary hypertension. In many
cases, somatic mutations in ion channels and pumps within adrenal cells initiate the …

In the 60 years that have passed since the discovery of the mineralocorticoid hormone
aldosterone, much has been learned about its synthesis (both adrenal and extra-adrenal) …

Primary aldosteronism (PA) is the most common form of endocrine hypertension and is
characterized by inappropriately elevated aldosterone production via a renin-independent …

The WGATAR motif is a common nucleotide sequence found in the transcriptional regulatory
regions of numerous genes. In vertebrates, these motifs are bound by one of six factors …

Primary aldosteronism is the most common single cause of hypertension and is potentially
curable when only one adrenal gland is the culprit. The importance of primary aldosteronism …

The biosynthesis of steroid hormones requires the coordinated expression of the enzymes
that comprise the pathways via which specific hormones are synthesized. These pathways …

Context: Aldosterone-producing adenomas (APA) are heterogeneous. The recent finding of
somatic KCNJ5 mutations suggests a genetic explanation. Objectives: The objectives of this …

Abstract Steroidogenic factor-1 (SF-1/Ad4BP; NR5A1), a nuclear receptor transcription
factor, has a pivotal role in adrenal and gonadal development in humans and mice. A …

The type 1 parathyroid hormone receptor (PTHR1) binds, with equal affinity, two ligands with
distinct biological functions: PTH, the major peptide hormone controlling calcium …

Context: The human adrenal gland produces small amounts of testosterone that are
increased under pathological conditions. However, the mechanisms through which the …