Sonic hedgehog (Shh) signaling is an essential central nervous system (CNS) pathway
involved during embryonic development and later life stages. Further, it regulates cell …

Sonic hedgehog (Shh) plays important roles in developmental of vertebrate animal central
nervous system (CNS), and Gli is its downstream signal molecule. Shh signalling is …

Sonic hedgehog (Shh) signaling influences neurogenesis and neural patterning during the
development of central nervous system. Dysregulation of Shh signaling in brain leads to …

Background Two recently developed novel rodent models have been reported to ablate
microglia, either by genetically targeting microglia (via Cx3cr1-creER: iDTR+ Dtx) or through …

The mesodiencephalic dopaminergic (mdDA) group of neurons comprises molecularly
distinct subgroups, of which the substantia nigra (SN) and ventral tegmental area (VTA) are …

Background/Aims: Neurite outgrowth and synaptogenesis are critical steps for functional
recovery after stroke. Resveratrol promotes neurite outgrowth and synaptogenesis, but the …

Abstract The Sonic Hedgehog (SHH) signaling pathway is related to the progression of
various tumors and nervous system diseases. Still, its specific role in neurodegenerative …

The degeneration of dopaminergic and other neurons in the aging brain is considered a
process starting well beyond the infantile and juvenile period. In contrast to other dopamine …

A model was previously proposed that DA neurons provide SHH ligand to striatal
interneurons, which in turn support the survival of DA neurons through the release of trophic …

Background Recent progress in the induced generation of dopaminergic (DA) neurons from
different types of stem cells or reprogrammed somatic cells holds tremendous potential for …