The potent pleiotropic lipid mediator sphingosine-1-phosphate (S1P) participates in
numerous cellular processes, including angiogenesis and cell survival, proliferation, and …

In Europe, almost 1000 children are diagnosed with a malignant renal tumour each year.
The vast majority of cases are nephroblastoma, also known as Wilms' tumour (WT). Most …

Cancer cells can move through tissues in a variety of different ways. In some cases, an
epithelial-to-mesenchymal transition enables cancer cells to acquire fibroblast-like migratory …

Cholangiocarcinoma (CCA) is an often fatal primary malignancy of the intra‐and
extrahepatic biliary tract that is commonly associated with chronic cholestasis and …

Sphingosine‐1‐phosphate (S1P) is a potent bioactive sphingolipid involved in cell
proliferation, angiogenesis, inflammation and malignant transformation among other …

G protein-coupled receptors (GPCRs) regulate an array of fundamental biological
processes, such as growth, metabolism and homeostasis. Specifically, GPCRs are involved …

Multiple Sclerosis (MS) is a chronic autoimmune disorder affecting the central nervous
system (CNS) through demyelination and neurodegeneration. Until recently, major …

S1P is a small bioactive lipid which exerts its effects following binding to a family of five G
protein-coupled receptors, known as S1P 1–5. Following receptor activation, multiple …

G-protein-coupled receptors (GPCRs), which represent the largest gene family in the human
genome, play a crucial role in multiple physiological functions as well as in tumor growth …

Hepatocellular carcinoma (HCC) is classified as a poor prognostic tumor, and becomes
frequently aggressive. MicroRNAs emerge as key contributors to tumor progression. This …