The discovery of the sensory nature of the carotid body dates back to the beginning of the
20th century. Following these seminal discoveries, research into carotid body mechanisms …

The respiratory response to hypoxia in mammals develops from an inhibition of breathing
movements in utero into a sustained increase in ventilation in the adult. This ventilatory …

Hypothalamic orexin/hypocretin neurons recently emerged as key orchestrators of brain
states and adaptive behaviors. They are critical for normal stimulation of wakefulness and …

Mammalian carotid bodies are the main peripheral arterial chemoreceptors, strategically
located at the bifurcation of the common carotid artery. When stimulated these receptors …

After defining the current approach to measuring the hypoxic ventilatory response this paper
explains why this method is not appropriate for comparisons between individuals or …

Mammalian carotid bodies are richly vascularized chemosensory organs that sense blood
levels of O2, CO2/H+, and glucose and maintain homeostatic regulation of these levels via …

Substantial advances have been made recently into the discovery of fundamental
mechanisms underlying the neural control of breathing and even some inroads into …

Adjustments of ventilation in fishes to regulate the volume of water flowing over the gills are
critically important responses to match branchial gas transfer with metabolic needs and to …

The importance of chemoreflex function for cardiovascular health is increasingly recognized
in clinical practice. The physiological function of the chemoreflex is to constantly adjust …

The motivation for this review comes from the emerging complexity of the autonomic
innervation of the carotid body (CB) and its putative role in regulating chemoreceptor …