The biological activity of androgens is thought to occur predominantly through binding to
intracellular androgen-receptors, a member of the nuclear receptor family, that interact with …

Prostate cancer has become a real public health issue in industrialized countries, mainly
due to patients' relapse by castration-refractory disease after androgen ablation. Castration …

Transcription factors are among the most attractive therapeutic targets but are considered
largely 'undruggable'in part due to the intrinsically disordered nature of their activation …

Androgen receptors (ARs) are phosphorylated at multiple sites in response to ligand
binding, but the kinases mediating AR phosphorylation and the importance of these kinases …

Abstract Context: Steroidogenic factor 1 (SF1/AdBP4/FTZF1, NR5A1) is a nuclear receptor
transcription factor that plays a key role in regulating adrenal and gonadal development …

Genetic aberrations of the androgen receptor (AR) caused by mutations, rearrangements,
and polymorphisms result in a mutant receptor that has varied functions compared to wild …

Steroidogenic factor 1 (SF1, NR5A1) is a nuclear receptor that regulates multiple genes
involved in adrenal and gonadal development, steroidogenesis, and the reproductive axis …

Our previous findings indicated that androgen receptor (AR) phosphorylation at serine 81 is
stimulated by the mitotic cyclin-dependent kinase 1 (CDK1). In this report, we extended our …

The nucleus is the primary site of protein aggregation in many polyglutamine diseases,
suggesting a central role in pathogenesis. In SBMA, the nucleus is further implicated by the …

Aberrant signaling by the androgen receptor contributes to the initiation and progression of
prostate cancer. The involvement of molecular chaperones in the processes of folding …