The deep evolutionary history of African populations, since the emergence of modern
humans more than 300,000 years ago, has resulted in high genetic diversity and …

Mutations in connexins are the most common causes of hearing impairment (HI) in many
populations. Our aim was to review the global burden of pathogenic and likely pathogenic …

Gene-environment (G x E) interactions significantly influence neurologic outcomes. The
maternal-placental-fetal (MPF) triad, neonate, or child less than 2 years may first exhibit …

We investigated hearing impairment (HI) in 51 families from Ghana with at least two affected
members that were negative for GJB2 pathogenic variants. DNA samples from 184 family …

The incidence of hearing impairment (HI) is higher in low-and middle-income countries
when compared to high-income countries. There is therefore a necessity to estimate the …

The rapid increase in genomics research in Africa and the growing promise of precision
public health (PPH) begs the question of whether African genomics has come of age and is …

Simple Summary The prevalence of GJB2-related (MIM: 121011) congenital non-syndromic
hearing impairment (NSHI) accounts for close to 50% in populations of Asian and European …

Hearing impairment (HI) is highly heterogeneous with over 123 associated genes reported
to date, mostly from studies among Europeans and Asians. Here, we performed a systematic …

Among the most prevalent neurodevelopmental disorders, Autism Spectrum Disorder (ASD)
is highly diverse showing a broad phenotypic spectrum. ASD also couples with a broad …

Simple Summary The incidence of the GJB2-p.(Arg143Trp) founder mutation in numerous
populations of different ethnolinguistic and geographical backgrounds has generated …