By modulating hepcidin production, an organism controls intestinal iron absorption, iron
uptake and mobilization from stores to meet body iron need. In recent years there has been …

There are two main mechanisms by which iron overload develops in thalassemias:
increased iron absorption due to ineffective erythropoiesis and blood transfusions. In …

Abstract β-thalassemia major causes ineffective erythropoiesis and chronic anemia and is
associated with iron overload due to both transfused iron and increased iron absorption, the …

Hemoglobin E (HbE) β-thalassemia is the most common severe thalassemia syndrome
across Asia, and millions of people are carriers. Clinical heterogeneity in HbE β-thalassemia …

Hepcidin, a peptide hormone that decreases intestinal iron absorption and macrophage iron
release, is a potential drug target for patients with iron overload syndromes because its …

The high iron demand associated with enhanced erythropoiesis during high-altitude hypoxia
leads to skeletal muscle iron mobilization and decrease in myoglobin protein levels. To …

This study investigated the effects of curcumin, the active polyphenol in turmeric, on iron
overload, hepcidin level, and liver function in β‐thalassemia major patients. This double …

BACKGROUND Hepcidin, a key regulator of iron metabolism, binds to the iron transporter
ferroportin to cause its degradation. In humans, hepcidin deficiency has been linked to …

BACKGROUND & AIMS: Parenchymal liver siderosis is associated with increased fibrosis in
patients with non-alcoholic fatty liver disease (NAFLD). The aim of this study was to assess …

Objectives To investigate potential usefulness of serum hepcidin in the diagnosis of iron
overload in children with β-thalassemia. Methods A study was conducted on 30 thalassemia …