Ageing is a major risk factor for the development of many diseases, prominently including
neurodegenerative disorders such as Alzheimer disease and Parkinson disease. A hallmark …

Ribosome-associated quality-control (RQC) surveys incomplete nascent polypeptides
produced by interrupted translation. Central players in RQC are the human ribosome-and …

Ubiquitin-fold modifier 1 (UFM1) is a ubiquitin-like protein covalently conjugated with
intracellular proteins through ufmylation, similar to ubiquitylation. Ufmylation is involved in …

The stalling of ribosomes during protein synthesis results in the production of truncated
polypeptides that can have deleterious effects on cells and therefore must be eliminated. In …

Ubiquitylation is an essential posttranslational modification that controls cell division,
differentiation, and survival in all eukaryotes. By combining multiple E3 ligases (writers) …

In recent years translation elongation has emerged as an important contributor to the
regulation of gene expression. There are multiple quality control checkpoints along the way …

Ribosomes that stall while translating cytosolic proteins are incapacitated by incomplete
nascent chains, termed “arrest peptides”(APs) that are destroyed by the ubiquitin …

Ribosome movement is not always smooth and is rather often impeded. For ribosome
pauses, fundamental issues remain to be addressed, including where ribosomes pause on …

Similar to many other biological molecules, RNA is vulnerable to chemical insults from
endogenous and exogenous sources. Noxious agents such as reactive oxygen species or …

Ribosome-associated quality control (RQC) represents a rescue pathway in eukaryotic cells
that is triggered upon translational stalling. Collided ribosomes are recognized for …