Terpenoids display chemical and structural diversities as well as important biological
activities. Despite their extreme variability, the range of these structures is limited by the …

The discovery of new enzymes, alongside the push to make chemical processes more
sustainable, has resulted in increased industrial interest in the use of biocatalytic processes …

l-Isoleucine dioxygenase (IDO) directly catalyzes the C–H bond hydroxylation of several
hydrophobic aliphatic amino acids. However, the ambiguous selectivity of IDO prevents its …

Deracemisation via chemo-enzymatic or multi-enzymatic approaches is the optimum
substitute for kinetic resolution, which suffers from the limitation of a theoretical maximum …

Epoxide hydrolases are attractive and industrially important biocatalysts. They can catalyze
the enantioselective hydrolysis of epoxides to the corresponding diols as chiral building …

By rational engineering of amidase, the efficient biocatalytic desymmetrization of meso O-
heterocyclic dicarboxamides for synthesizing both antipodes of functionalized cyclic motifs …

Microbial epoxide hydrolases, cis-Epoxysuccinate hydrolases (CESHs) have been utilized
for commercial production of enantiomerically pure L (+)-and D (-)-tartaric acids for decades …

Both the activity and regioselectivity of Phaseolus vulgaris epoxide hydrolase were
remarkably improved via reshaping two substrate tunnels based on rational design. The …

Transaminases show potential for the industrial synthesis of important pharmaceutical
ingredients. However, these naturally occurring enzymes show poor activity toward bulky N …

Abstract (R)‐Phenylglycinol is an important chiral building block for pharmaceutical and fine
chemical industry, and its efficient synthesis from cheap and commercially available starting …