The glutathione (GSH) system is considered to be one of the most powerful endogenous
antioxidant systems in the cardiovascular system due to its key contribution to detoxifying …

Beyond their role as a cellular powerhouse, mitochondria are emerging as integral players
in molecular signaling and cell fate determination through reactive oxygen species (ROS) …

Ischemic heart disease still represents a large burden on individuals and health care
resources worldwide. By conventions, it is equated with atherosclerotic plaque due to flow …

Many treatments have been identified that confer robust cardioprotection in experimental
animal models of acute ischemia and reperfusion injury. However, translation of these …

COVID‐19 may cause pneumonia, acute respiratory distress syndrome, cardiovascular
alterations, and multiple organ failure, which have been ascribed to a cytokine storm, a …

Ischemic heart disease (IHD) is the leading cause of disability and mortality worldwide.
Reactive oxygen species (ROS) have been shown to play key roles in the progression of …

Oxidative stress, which results in the damage of diverse biological molecules, is a ubiquitous
cellular process implicated in the etiology of many illnesses. The sulfhydryl-containing …

N-acetylcysteine (NAC) is a medicine widely used to treat paracetamol overdose and as a
mucolytic compound. It has a well-established safety profile, and its toxicity is uncommon …

abstract Glucose is a key metabolite used by cancer cells to generate ATP, maintain redox
state and create biomass. Glucose can be catabolized to lactate in the cytoplasm, which is …

Primary percutaneous coronary intervention is nowadays the preferred reperfusion strategy
for patients with acute ST-segment–elevation myocardial infarction, aiming at restoring …