Aging is characterized by a progressive decline in the normal physiological functions of an
organism, ultimately leading to mortality. Nicotinamide adenine dinucleotide (NAD+) is an …

Mitochondria are remarkably dynamic organelles that migrate, divide and fuse. Cycles of
mitochondrial fission and fusion ensure metabolite and mitochondrial DNA mixing and …

Mitochondria are highly mobile and dynamic organelles that continually fuse and divide.
These processes allow mitochondria to exchange contents, including mitochondrial DNA …

Parkinson's disease is a pervasive, ageing-related neurodegenerative disease the cardinal
motor symptoms of which reflect the loss of a small group of neurons, the dopaminergic …

Human neurodegenerative diseases are devastating illnesses that predominantly affect
elderly people. The majority of the diseases are associated with pathogenic oligomers from …

Mitochondria play pivotal roles in most eukaryotic cells, ranging from energy production to
regulation of apoptosis. As sites of cellular respiration, mitochondria experience …

Over the past years, knowledge and evidence about the existence of crosstalks between
cellular organelles and their potential effects on survival or cell death have been constantly …

Organismal aging is accompanied by a host of progressive metabolic alterations and an
accumulation of senescent cells, along with functional decline and the appearance of …

Telomerase plays an important role in cellular proliferation capacity and survival under
conditions of stress. A large part of this protective function is due to telomere capping and …

Ubiquinone (UQ) is implicated in mitochondrial electron transport, superoxide generation
and as a membrane antioxidant. Here we present a mouse model in which UQ biosynthesis …