Osteoporosis and Alzheimer´ s disease (or Alzheimer´ s disease and Osteoporosis)

NE Wanionok, GR Morel, JM Fernández - Ageing Research Reviews, 2024 - Elsevier
Alzheimer's disease (AD) and osteoporosis are two diseases that mainly affect elderly
people, with increases in the occurrence of cases due to a longer life expectancy. Several …

Crosstalk of brain and bone—clinical observations and their molecular bases

E Otto, PR Knapstein, D Jahn, J Appelt… - International journal of …, 2020 - mdpi.com
As brain and bone disorders represent major health issues worldwide, substantial clinical
investigations demonstrated a bidirectional crosstalk on several levels, mechanistically …

Mind the gap: unraveling the intricate dance between Alzheimer's disease and related dementias and bone health

SJ Karnik, TJ Margetts, HS Wang, A Movila… - Current Osteoporosis …, 2024 - Springer
Abstract Purpose of Review This review examines the linked pathophysiology of Alzheimer's
disease/related dementia (AD/ADRD) and bone disorders like osteoporosis. The emphasis …

[HTML][HTML] Therapeutic potential of iron chelators on osteoporosis and their cellular mechanisms

J Zhang, H Zhao, G Yao, P Qiao, L Li, S Wu - Biomedicine & …, 2021 - Elsevier
Iron is an essential trace element in the metabolism of almost all living organisms. Iron
overload can disrupt bone homeostasis by significant inhibition of osteogenic differentiation …

Association of bone mineral density and dementia: the Rotterdam study

T Xiao, S Ghatan, SS Mooldijk, K Trajanoska, L Oei… - Neurology, 2023 - AAN Enterprises
Background and Objectives Low bone mineral density (BMD) and dementia commonly co-
occur in older individuals, with bone loss accelerating in patients with dementia due to …

COVID-19: Could Irisin Become the Handyman Myokine of the 21st Century?

A Catalano - Coronaviruses, 2020 - benthamdirect.com
The ongoing Coronavirus disease 2019 (COVID-19) outbreak in China has become the
world's leading health headline and is causing major panic and public concerns. After …

Attenuation of Alzheimer's brain pathology in 5XFAD mice by PTH1-34, a peptide of parathyroid hormone

L Chen, L Xiong, L Yao, J Pan, E Arzola, X Zhu… - Alzheimer's research & …, 2023 - Springer
Background Alzheimer's disease (AD) and osteoporosis are two distinct diseases but often
occur in the same patient. Their relationship remains poorly understood. Studies using …

Effects of 6-month multimodal physical exercise program on bone mineral density, fall risk, balance, and gait in patients with Alzheimer's disease: a controlled clinical …

AS Puente-Gonzalez, MC Sanchez-Sanchez… - Brain Sciences, 2021 - mdpi.com
We aimed to determine the short-and medium-term effects of a multimodal physical exercise
program (MPEP) on bone health status, fall risk, balance, and gait in patients with …

Bone and lean mass loss and cognitive impairment for healthy elder adults: analysis of the nutrition and health survey in Taiwan 2013–2016 and a validation study …

SF Lin, YC Fan, WH Pan, CH Bai - Frontiers in nutrition, 2021 - frontiersin.org
Purpose: Bone and lean mass loss and cognitive impairment are prevalent in elder adults
and have been hypothesized to share a potential link. Methods: This nationwide cross …

Degradation of Bone Quality in a Transgenic Mouse Model of Alzheimer′ s Disease

JE LLabre, C Gil, N Amatya, S Lagalwar… - Journal of Bone and …, 2020 - academic.oup.com
Alzheimer′ s disease (AD) patients present with symptoms such as impairment of insulin
signaling, chronic inflammation, and oxidative stress. Furthermore, there are comorbidities …