Activation of microglia and astrocytes secondary to inflammatory processes contributes to
the development and perpetuation of pain with a neuropathic phenotype. This pain state …

As a model of lipid rafts, the liquid-ordered (Lo) phase formed by sphingomyelin (SM) and
cholesterol (Cho) in bilayer membranes has long attracted the attention of biophysics …

Tools based on artificial intelligence (AI) are currently revolutionising many fields, yet their
applications are often limited by the lack of suitable training data in programmatically …

Doxorubicin (DOX) is one of the most efficient antitumor drugs employed in numerous
cancer therapies. Its incorporation into lipid-based nanocarriers, such as liposomes …

The chain melting of lipid bilayers has often been investigated in detail using calorimetric
methods, such as differential scanning calorimetry (DSC), and the resultant main transition …

Most phospholipids constituting biological membranes are chiral molecules with a
hydrophilic head group and hydrophobic alkyl chains, rendering biphasic property …

NMR is a sophisticated method for investigation of structure and dynamics of lipid and
protein molecules in membranes. Vibrational spectroscopy is also powerful because of …

Amphotericin B (AmB) has been clinically used for serious fungal infections for over 60
years. The drug is characterized by its specific recognition of ergosterol (Erg) in the fungal …

Sialic acid-containing glycoconjugates are involved in important biological processes such
as immune response, cancer metastasis, and viral infection. However, their chemical …

In this review, we deal with the flexible structures of small biomolecules and discuss how
spontaneous conformational changes are related to their biological functions, mainly …