There have been many ups and downs since the introduction of gene therapy as a
therapeutic modality for diseases. However, the journey of gene therapy has reached a …

The discovery of clustered regularly interspaced short palindromic repeats (CRISPR)
genome editing technology opened the door to provide a versatile approach for treating …

Infection with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) causes
Coronavirus Disease 2019 (COVID-19), which has reached pandemic proportions. A …

Oncolytic adenovirus therapy is gaining importance as a novel treatment option for the
management of various cancers. Different concepts of modification within the adenovirus …

Gene therapy is becoming an increasingly valuable tool to treat many genetic diseases with
no or limited treatment options. This is the case for hundreds of monogenic metabolic …

Inactivated and live attenuated vaccines have improved human life and significantly reduced
morbidity and mortality of several human infectious diseases. However, these vaccines have …

Viruses elicit cell and organismic stress, and offset homeostasis. They trigger intrinsic, innate
and adaptive immune responses, which limit infection. Viruses restore homeostasis by …

Targeted chromosomal insertion of large genetic payloads in human cells leverages and
broadens synthetic biology and genetic therapy efforts. Yet, obtaining large-scale gene …

Highlights•Stability and built-in weaknesses are emergent properties of adenovirus particles
and key for gene delivery.•Entry is a gain of function process where the virion uncoats in a …

Both well‐known and emerging viruses increasingly affect humans and cause disease,
sometimes with devastating impact on society. The viruses present in the biosphere are the …