Fragment‐based drug discovery (FBDD) is now established as a complementary approach
to high‐throughput screening (HTS). Contrary to HTS, where large libraries of drug‐like …

This Perspective is the seventh in an annual series that summarizes successful Fragment-to-
Lead (F2L) case studies published in a given year. A tabulated summary of relevant articles …

Drug discovery relies on the knowledge of not only drugs and targets, but also the
comparative agents and targets. These include poor binders and non-binders for developing …

Prior research has shown an elevation in autism traits and diagnoses in individuals seen for
gender related consultation and in participants self-identifying as transgender. To …

While nuclear magnetic resonance (NMR) is regarded as a reference in fragment-based
drug design, its implementation in a high-throughput manner is limited by its lack of …

Protein–protein interactions (PPIs) have important roles in various cellular processes, but
are commonly described as 'undruggable'therapeutic targets due to their large, flat …

Macrodomains are a class of conserved ADP-ribosylhydrolases expressed by viruses of
pandemic concern, including coronaviruses and alphaviruses. Viral macrodomains are …

Current fragment-based drug design relies on the efficient exploration of chemical space by
using structurally diverse libraries of small fragments. However, structurally dissimilar …

Background: Open Access Perspective The Conserved Macrodomain Is a Potential
Therapeutic Target for Coronaviruses and Alphaviruses by Anthony KL Leung 1, 2, 3, 4 …

The main protease (3CLp) of the SARS‐CoV‐2, the causative agent for the COVID‐19
pandemic, is one of the main targets for drug development. To be active, 3CLp relies on a …