Oxidative stress in apoptosis and cancer: an update
The oxygen paradox tells us that oxygen is both necessary for aerobic life and toxic to all life
forms. Reactive oxygen species (ROS) touch every biological and medical discipline …
forms. Reactive oxygen species (ROS) touch every biological and medical discipline …
Hydrogels in spinal cord injury repair: A review
Z Lv, C Dong, T Zhang, S Zhang - Frontiers in bioengineering and …, 2022 - frontiersin.org
Traffic accidents and falling objects are responsible for most spinal cord injuries (SCIs). SCI
is characterized by high disability and tends to occur among the young, seriously affecting …
is characterized by high disability and tends to occur among the young, seriously affecting …
Quercetin prevents necroptosis of oligodendrocytes by inhibiting macrophages/microglia polarization to M1 phenotype after spinal cord injury in rats
H Fan, HB Tang, LQ Shan, SC Liu, DG Huang… - Journal of …, 2019 - Springer
Abstract Background Oligodendrocytes (OLs) death after spinal cord injury (SCI) contributes
to demyelination, even leading to a permanent neurological deficit. Besides apoptosis, our …
to demyelination, even leading to a permanent neurological deficit. Besides apoptosis, our …
Neuron and microglia/macrophage-derived FGF10 activate neuronal FGFR2/PI3K/Akt signaling and inhibit microglia/macrophages TLR4/NF-κB-dependent …
Therapeutics used to treat central nervous system (CNS) injury were designed to repair
neurites and inhibit cell apoptosis. Previous studies have shown that neuron-derived FGF10 …
neurites and inhibit cell apoptosis. Previous studies have shown that neuron-derived FGF10 …
Exosomes from bone marrow mesenchymal stem cells inhibit neuronal apoptosis and promote motor function recovery via the Wnt/β-catenin signaling pathway
C Li, G Jiao, W Wu, H Wang, S Ren… - Cell …, 2019 - journals.sagepub.com
Severe spinal cord injury (SCI) is caused by external mechanical injury, resulting in
unrecoverable neurological injury. Recent studies have shown that exosomes derived from …
unrecoverable neurological injury. Recent studies have shown that exosomes derived from …
Using NGF heparin-poloxamer thermosensitive hydrogels to enhance the nerve regeneration for spinal cord injury
Objective Nerve growth factor (NGF) has potential in spinal cord injury (SCI) therapy, but
limited by the poor physicochemical stability and low ability to cross the blood spinal cord …
limited by the poor physicochemical stability and low ability to cross the blood spinal cord …
Regulation of autophagy and ubiquitinated protein accumulation by bFGF promotes functional recovery and neural protection in a rat model of spinal cord injury
HY Zhang, ZG Wang, FZ Wu, XX Kong, J Yang… - Molecular …, 2013 - Springer
The role of autophagy in the recovery of spinal cord injury remains controversial; in
particular, the mechanism of autophagy regulated degradation of ubiquitinated proteins has …
particular, the mechanism of autophagy regulated degradation of ubiquitinated proteins has …
RIPK1/RIPK3/MLKL-mediated necroptosis contributes to compression-induced rat nucleus pulposus cells death
S Chen, X Lv, B Hu, Z Shao, B Wang, K Ma, H Lin… - Apoptosis, 2017 - Springer
The aim of this study was to systematically investigate the role of necroptosis in compression-
induced rat nucleus pulposus (NP) cells death, as well as explore the underlying …
induced rat nucleus pulposus (NP) cells death, as well as explore the underlying …
Necroptosis inhibitor necrostatin-1 promotes cell protection and physiological function in traumatic spinal cord injury
Y Wang, H Wang, Y Tao, S Zhang, J Wang, X Feng - Neuroscience, 2014 - Elsevier
Spinal cord injury (SCI) is a common and serious trauma which lacks efficient treatment.
Inhibition of cell death in the trauma area is important for spinal cord protection during this …
Inhibition of cell death in the trauma area is important for spinal cord protection during this …
An anti-inflammatory peptide and brain-derived neurotrophic factor-modified hyaluronan-methylcellulose hydrogel promotes nerve regeneration in rats with spinal …
Z He, H Zang, L Zhu, K Huang, T Yi… - International Journal …, 2019 - Taylor & Francis
Background Traumatic spinal cord injury (SCI) causes neuronal death, demyelination,
axonal degeneration, inflammation, glial scar formation, and cystic cavitation resulting in …
axonal degeneration, inflammation, glial scar formation, and cystic cavitation resulting in …