[HTML][HTML] Protective mechanisms and current clinical evidence of hypothermic oxygenated machine perfusion (HOPE) in preventing post-transplant cholangiopathy

A Schlegel, RJ Porte, P Dutkowski - Journal of Hepatology, 2022 - Elsevier
The development of cholangiopathies after liver transplantation impacts on the quality and
duration of graft and patient survival, contributing to higher costs as numerous interventions …

Challenges to liver transplantation and strategies to improve outcomes

P Dutkowski, M Linecker, ML DeOliveira, B Müllhaupt… - Gastroenterology, 2015 - Elsevier
Liver transplantation (LT) is a highly successful treatment for many patients with
nonmalignant and malignant liver diseases. However, there is a worldwide shortage of …

Hypothermic machine perfusion in liver transplantation—a randomized trial

R van Rijn, IJ Schurink, Y de Vries… - … England Journal of …, 2021 - Mass Medical Soc
Background Transplantation of livers obtained from donors after circulatory death is
associated with an increased risk of nonanastomotic biliary strictures. Hypothermic …

First comparison of hypothermic oxygenated perfusion versus static cold storage of human donation after cardiac death liver transplants: an international-matched …

P Dutkowski, WG Polak, P Muiesan, A Schlegel… - Annals of …, 2015 - journals.lww.com
Background: Exposure of donor liver grafts to prolonged periods of warm ischemia before
procurement causes injuries including intrahepatic cholangiopathy, which may lead to graft …

Dual hypothermic oxygenated machine perfusion in liver transplants donated after circulatory death

R van Rijn, N Karimian, APM Matton… - Journal of British …, 2017 - academic.oup.com
Background Experimental studies have suggested that end-ischaemic dual hypothermic
oxygenated machine perfusion (DHOPE) may restore hepatocellular energy status and …

A multicentre outcome analysis to define global benchmarks for donation after circulatory death liver transplantation

A Schlegel, M van Reeven, K Croome, A Parente… - Journal of …, 2022 - Elsevier
Background & Aims The concept of benchmarking is established in the field of transplant
surgery; however, benchmark values for donation after circulatory death (DCD) liver …

HOPE for human liver grafts obtained from donors after cardiac death

P Dutkowski, A Schlegel, M de Oliveira, B Müllhaupt… - Journal of …, 2014 - Elsevier
Background & Aims Due to ethical rules in most countries, long ischemia times are
unavoidable prior to organ procurement of donors without a heartbeat, which can cause …

The UK DCD Risk Score: a new proposal to define futility in donation-after-circulatory-death liver transplantation

A Schlegel, M Kalisvaart, I Scalera, RW Laing… - Journal of …, 2018 - Elsevier
Background & Aims Primary non-function and ischaemic cholangiopathy are the most feared
complications following donation-after-circulatory-death (DCD) liver transplantation. The aim …

[HTML][HTML] Biliary complications after liver transplantation: old problems and new challenges

D Seehofer, D Eurich, W Veltzke-Schlieker… - American Journal of …, 2013 - Elsevier
Due to a vulnerable blood supply of the bile ducts, biliary complications are a major source
of morbidity after liver transplantation (LT). Manifestation is either seen at the anastomotic …

[HTML][HTML] American Society of Transplant Surgeons recommendations on best practices in donation after circulatory death organ procurement

KP Croome, AS Barbas, B Whitson, A Zarrinpar… - American Journal of …, 2023 - Elsevier
Abstract The American Society of Transplant Surgeons supports efforts to increase the
number of organs that are critically needed for patients desperately awaiting transplantation …