Senescence in human mesenchymal stem cells: functional changes and implications in stem cell-based therapy

V Turinetto, E Vitale, C Giachino - International journal of molecular …, 2016 - mdpi.com
Regenerative medicine is extensively interested in developing cell therapies using
mesenchymal stem cells (MSCs), with applications to several aging-associated diseases …

Relevance of oxygen concentration in stem cell culture for regenerative medicine

C Mas-Bargues, J Sanz-Ros… - International journal of …, 2019 - mdpi.com
The key hallmark of stem cells is their ability to self-renew while keeping a differentiation
potential. Intrinsic and extrinsic cell factors may contribute to a decline in these stem cell …

[HTML][HTML] Comparative analysis of human mesenchymal stem cells from bone marrow, adipose tissue, and umbilical cord blood as sources of cell therapy

HJ Jin, YK Bae, M Kim, SJ Kwon, HB Jeon… - International journal of …, 2013 - mdpi.com
Various source-derived mesenchymal stem cells (MSCs) have been considered for cell
therapeutics in incurable diseases. To characterize MSCs from different sources, we …

[HTML][HTML] Usage of human mesenchymal stem cells in cell-based therapy: advantages and disadvantages

HJ Kim, JS Park - Development & reproduction, 2017 - ncbi.nlm.nih.gov
The use of human mesenchymal stem cells (hMSCs) in cell-based therapy has attracted
extensive interest in the field of regenerative medicine, and it shows applications to …

Genetic stability of mesenchymal stromal cells for regenerative medicine applications: a fundamental biosafety aspect

S Neri - International journal of molecular sciences, 2019 - mdpi.com
Mesenchymal stem/stromal cells (MSC) show widespread application for a variety of clinical
conditions; therefore, their use necessitates continuous monitoring of their safety. The risk …

Hypoxia-conditioned mesenchymal stem cells in tissue regeneration application

Y Yang, EH Lee, Z Yang - Tissue Engineering Part B: Reviews, 2022 - liebertpub.com
Mesenchymal stem cells (MSCs) have been demonstrated as promising cell sources for
tissue regeneration due to their capability of self-regeneration, differentiation, and …

Discrepancies on the role of oxygen gradient and culture condition on mesenchymal stem cell fate

JRK Samal, VK Rangasami, S Samanta… - Advanced …, 2021 - Wiley Online Library
Over the past few years, mesenchymal stem (or stromal) cells (MSCs) have garnered
enormous interest due to their therapeutic value especially for their multilineage …

Molecular mechanisms contributing to mesenchymal stromal cell aging

S Neri, RM Borzì - Biomolecules, 2020 - mdpi.com
Mesenchymal stem/stromal cells (MSCs) are a reservoir for tissue homeostasis and repair
that age during organismal aging. Beside the fundamental in vivo role of MSCs, they have …

Hypoxic preconditioning induces the expression of prosurvival and proangiogenic markers in mesenchymal stem cells

SM Chacko, S Ahmed, K Selvendiran… - … of Physiology-Cell …, 2010 - journals.physiology.org
Stem cells transplanted to the ischemic myocardium usually encounter massive cell death
within a few days of therapy. Hypoxic preconditioning (HPC) is currently employed as a …

Cellular senescence in aging and osteoarthritis: implications for cartilage repair

WS Toh, M Brittberg, J Farr, CB Foldager… - Acta …, 2016 - Taylor & Francis
It is well accepted that age is an important contributing factor to poor cartilage repair
following injury, and to the development of osteoarthritis. Cellular senescence, the loss of …