The upcoming 11th revision of the International Statistical Classification of Diseases and
Related Health Problems (ICD) of the World Health Organization (WHO) offers a unique …

Pain is a hallmark of tissue injury, inflammatory diseases, pathogen invasion and
neuropathy. It is mediated by nociceptor sensory neurons that innervate the skin, joints …

Pre-diabetes and diabetes are a global epidemic, and the associated neuropathic
complications create a substantial burden on both the afflicted patients and society as a …

Neuropathic pain is a frequent condition caused by a lesion or disease of the central or
peripheral somatosensory nervous system. A frequent cause of peripheral neuropathic pain …

Allodynia (pain due to a stimulus that does not usually provoke pain) and hyperalgesia
(increased pain from a stimulus that usually provokes pain) are prominent symptoms in …

Dorsal root ganglion (DRG) sensory neuron subtypes defined by their in vivo properties
display distinct intrinsic electrical properties. We used bulk RNA sequencing of genetically …

After nerve injury maladaptive changes can occur in injured sensory neurons and along the
entire nociceptive pathway within the CNS, which may lead to spontaneous pain or pain …

Next-generation transcriptomics in combination with imaging-based approaches have
emerged as powerful tools for the characterization of dorsal root ganglion (DRG) neuronal …

In neuropathic pain it has been suggested that pain phenotype based on putative pain
mechanisms may predict response to treatment. This was a randomised, double-blind …

The voltage-gated sodium channel NaV1. 7 is preferentially expressed in peripheral somatic
and visceral sensory neurons, olfactory sensory neurons and sympathetic ganglion neurons …