The intestine is one of the major organs in C. elegans and is largely responsible for food
digestion and assimilation as well as the synthesis and storage of macromolecules. In …

Caenorhabditis elegans (C. elegans) is a free-living nematode that has been extensively
utilized as an animal model for research involving aging and neurodegenerative diseases …

Monomethyl branched-chain fatty acids (mmBCFAs) are commonly found in many
organisms from bacteria to mammals. In humans, they have been detected in skin, brain …

Understanding the regulation of fat synthesis and the consequences of its misregulation is of
profound significance for managing the obesity epidemic and developing obesity …

As in all living organisms, survival in C. elegans requires adequate management of energy
supplies. Genetic screens have revealed that C. elegans fat regulation involves a complex …

In algae, the biosynthesis of docosahexaenoic acid (22: 6ω3; DHA) proceeds via the
elongation of eicosapentaenoic acid (20: 5ω3; EPA) to 22: 5ω3, which is required as a …

Many lifespan-modulating genes are involved in either generation of oxidative substrates
and end-products, or their detoxification and removal. Among such metabolites, only …

Dietary fat accumulates in lipid droplets or endolysosomal compartments that undergo
selective expansion under normal or pathophysiological conditions. We find that genetic …

A variety of lipid and lipid-derived molecules can modulate TRP cation channel activity, but
the identity of the lipids that affect TRP channel function in vivo is unknown. Here, we use …

Background Animal models are indispensable to understand the lipid metabolism and lipid
metabolic diseases. Over the last decade, the nematode Caenorhabditis elegans has …