Evaluation of pharmacokinetic drug–drug interactions: a review of the mechanisms, in vitro and in silico approaches
Y Peng, Z Cheng, F Xie - Metabolites, 2021 - mdpi.com
Pharmacokinetic drug–drug interactions (DDIs) occur when a drug alters the absorption,
transport, distribution, metabolism or excretion of a co-administered agent. The occurrence …
transport, distribution, metabolism or excretion of a co-administered agent. The occurrence …
From endogenous compounds as biomarkers to plasma‐derived nanovesicles as liquid biopsy; has the golden age of translational pharmacokinetics‐absorption …
D Rodrigues, A Rowland - Clinical Pharmacology & …, 2019 - Wiley Online Library
It is now established that a drug's pharmacokinetics (PK) absorption, distribution,
metabolism, excretion (ADME) and drug–drug interaction (DDI) profile can be modulated by …
metabolism, excretion (ADME) and drug–drug interaction (DDI) profile can be modulated by …
Time-dependent enzyme inactivation: numerical analyses of in vitro data and prediction of drug-drug interactions
J Yadav, E Paragas, K Korzekwa, S Nagar - Pharmacology & therapeutics, 2020 - Elsevier
Cytochrome P450 (CYP) enzyme kinetics often do not conform to Michaelis-Menten
assumptions, and time-dependent inactivation (TDI) of CYPs displays complexities such as …
assumptions, and time-dependent inactivation (TDI) of CYPs displays complexities such as …
Considerations from the Innovation and Quality Induction Working Group in response to drug-drug interaction guidance from regulatory agencies: guidelines on model …
SG Wong, D Ramsden, S Dallas, C Fung… - Drug Metabolism and …, 2021 - ASPET
Translational and ADME Sciences Leadership Group Induction Working Group (IWG)
presents an analysis on the time course for cytochrome P450 induction in primary human …
presents an analysis on the time course for cytochrome P450 induction in primary human …
Improved predictions of drug–drug interactions mediated by time-dependent inhibition of CYP3A
J Yadav, K Korzekwa, S Nagar - Molecular pharmaceutics, 2018 - ACS Publications
Time-dependent inactivation (TDI) of cytochrome P450s (CYPs) is a leading cause of clinical
drug–drug interactions (DDIs). Current methods tend to overpredict DDIs. In this study, a …
drug–drug interactions (DDIs). Current methods tend to overpredict DDIs. In this study, a …
Application of new cellular and microphysiological systems to drug metabolism optimization and their positioning respective to in silico tools
L Docci, N Parrott, S Krähenbühl… - … Life Sciences R&D, 2019 - journals.sagepub.com
New cellular model systems for drug metabolism applications, such as advanced 2D liver co-
cultures, spheroids, and microphysiological systems (MPSs), offer exciting opportunities to …
cultures, spheroids, and microphysiological systems (MPSs), offer exciting opportunities to …
Perspectives from the innovation and quality consortium induction working group on factors impacting clinical drug-drug interactions resulting from induction: focus on …
A recent publication from the Innovation and Quality Consortium Induction Working Group
collated a large clinical data set with the goal of evaluating the accuracy of drug-drug …
collated a large clinical data set with the goal of evaluating the accuracy of drug-drug …
Incompatibility of chemical protein synthesis inhibitors with accurate measurement of extended protein degradation rates
C Chan, P Martin, NJ Liptrott, M Siccardi… - Pharmacology …, 2017 - Wiley Online Library
Protein synthesis inhibitors are commonly used for measuring protein degradation rates, but
may cause cytotoxicity via direct or indirect mechanisms. This study aimed to identify …
may cause cytotoxicity via direct or indirect mechanisms. This study aimed to identify …
[HTML][HTML] Derivation of CYP3A4 and CYP2B6 degradation rate constants in primary human hepatocytes: A siRNA-silencing-based approach
CYS Chan, O Roberts, RKR Rajoli, NJ Liptrott… - Drug Metabolism and …, 2018 - Elsevier
The first-order degradation rate constant (k deg) of cytochrome P450 (CYP) enzymes is a
known source of uncertainty in the prediction of time-dependent drug–drug interactions …
known source of uncertainty in the prediction of time-dependent drug–drug interactions …
[HTML][HTML] Simultaneous assessment of clearance, metabolism, induction, and drug-drug interaction potential using a long-term in vitro liver model for a novel hepatitis B …
NA Kratochwil, M Triyatni, MB Mueller… - … of Pharmacology and …, 2018 - ASPET
Long-term in vitro liver models are now widely explored for human hepatic metabolic
clearance prediction, enzyme phenotyping, cross-species metabolism, comparison of low …
clearance prediction, enzyme phenotyping, cross-species metabolism, comparison of low …