Macrophage functional diversity in NAFLD—more than inflammation
Macrophages have diverse phenotypes and functions due to differences in their origin,
location and pathophysiological context. Although their main role in the liver has been …
location and pathophysiological context. Although their main role in the liver has been …
The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis
K Kazankov, SMD Jørgensen, KL Thomsen… - Nature reviews …, 2019 - nature.com
Nonalcoholic fatty liver disease (NAFLD) and its inflammatory and often progressive subtype
nonalcoholic steatohepatitis (NASH) are becoming the leading cause of liver-related …
nonalcoholic steatohepatitis (NASH) are becoming the leading cause of liver-related …
Tumour extracellular vesicles and particles induce liver metabolic dysfunction
Cancer alters the function of multiple organs beyond those targeted by metastasis,. Here we
show that inflammation, fatty liver and dysregulated metabolism are hallmarks of …
show that inflammation, fatty liver and dysregulated metabolism are hallmarks of …
Dynamic shifts in the composition of resident and recruited macrophages influence tissue remodeling in NASH
S Daemen, A Gainullina, G Kalugotla, L He, MM Chan… - Cell reports, 2021 - cell.com
Macrophage-mediated inflammation is critical in the pathogenesis of non-alcoholic
steatohepatitis (NASH). Here, we describe that, with high-fat, high-sucrose-diet feeding …
steatohepatitis (NASH). Here, we describe that, with high-fat, high-sucrose-diet feeding …
[HTML][HTML] Invited review: The influence of immune activation on transition cow health and performance—A critical evaluation of traditional dogmas
The progression from gestation into lactation represents the transition period, and it is
accompanied by marked physiological, metabolic, and inflammatory adjustments. The entire …
accompanied by marked physiological, metabolic, and inflammatory adjustments. The entire …
Chronic tissue inflammation and metabolic disease
YS Lee, J Olefsky - Genes & development, 2021 - genesdev.cshlp.org
Obesity is the most common cause of insulin resistance, and the current obesity epidemic is
driving a parallel rise in the incidence of T2DM. It is now widely recognized that chronic …
driving a parallel rise in the incidence of T2DM. It is now widely recognized that chronic …
Mechanisms of fibrosis development in nonalcoholic steatohepatitis
Nonalcoholic fatty liver disease is the most prevalent liver disease worldwide, affecting 20%–
25% of the adult population. In 25% of patients, nonalcoholic fatty liver disease progresses …
25% of the adult population. In 25% of patients, nonalcoholic fatty liver disease progresses …
Links between metabolic syndrome and metabolic dysfunction-associated fatty liver disease
S Lim, JW Kim, G Targher - Trends in Endocrinology & Metabolism, 2021 - cell.com
Metabolic dysfunction-associated fatty liver disease (MAFLD) is a chronic condition
characterized by hepatic fat accumulation combined with underlying metabolic …
characterized by hepatic fat accumulation combined with underlying metabolic …
The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)
Nonalcoholic fatty liver disease (NAFLD) is increasingly prevalent and represents a growing
challenge in terms of prevention and treatment. Despite its high prevalence, only a small …
challenge in terms of prevention and treatment. Despite its high prevalence, only a small …
[HTML][HTML] Dual regularized unsupervised feature selection based on matrix factorization and minimum redundancy with application in gene selection
Gene expression data have become increasingly important in machine learning and
computational biology over the past few years. In the field of gene expression analysis …
computational biology over the past few years. In the field of gene expression analysis …