The kidneys are frequently targeted by pathogenic immune responses against renal
autoantigens or by local manifestations of systemic autoimmunity. Recent studies in rodent …

Dendritic cells (DCs) are chief inducers of adaptive immunity and regulate local
inflammatory responses across the body. Together with macrophages, the other main type of …

Regulatory T (Treg) cells that express the transcription factor forkhead box protein P3
(FOXP3) are naturally present in the immune system and have roles in the maintenance of …

Glomerular diseases are common and important. They can arise from systemic inflammatory
or metabolic diseases that affect the kidney. Alternately, they are caused primarily by local …

Chemokines and chemokine receptors are implicated in regulatory T cell (Treg) trafficking to
sites of inflammation and suppression of excessive immune responses in inflammatory and …

FoxP3+ regulatory T cells (Tregs) play crucial roles in peripheral immune tolerance. In
addition, Tregs that reside or accumulate in nonlymphoid tissues, called tissue Tregs, exhibit …

Regulatory T cells (Tregs) have been shown to be important in maintaining immune
homeostasis and preventing autoimmune disease, including autoimmune kidney disease. It …

The kidney is vulnerable to injury, both acute and chronic from a variety of immune and
metabolic insults, all of which at least to some degree involve inflammation. Regulatory T …

Pro-inflammatory CD4+ T cells are major drivers of autoimmune diseases, yet therapies
modulating T cell phenotypes to promote an anti-inflammatory state are lacking. Here, we …

Cells expressing both the regulatory T cell (Treg)-inducing transcription factor Foxp3 and the
Th17 transcription factor RORγt have been identified (biTregs). It is unclear whether RORγt+ …