Monoaminergic neuropathology in Alzheimer's disease

G Šimić, MB Leko, S Wray, CR Harrington… - Progress in …, 2017 - Elsevier
None of the proposed mechanisms of Alzheimer's disease (AD) fully explains the distribution
patterns of the neuropathological changes at the cellular and regional levels, and their …

The physiological and pathophysiological roles of neuronal histamine: an insight from human positron emission tomography studies

K Yanai, M Tashiro - Pharmacology & therapeutics, 2007 - Elsevier
Histamine neurons are exclusively located in the posterior hypothalamus, and project their
fibers to almost all regions of the human brain. Although a significant amount of research …

Imaging of central itch modulation in the human brain using positron emission tomography

H Mochizuki, M Tashiro, M Kano, Y Sakurada, M Itoh… - Pain, 2003 - journals.lww.com
The unpleasantness of itching is reduced by cooling. Although previous research suggests
the presence of a central itch modulation system, there is little documentation about the …

The human histaminergic system in neuropsychiatric disorders

L Shan, AM Bao, DF Swaab - Trends in neurosciences, 2015 - cell.com
Histaminergic neurons are exclusively located in the hypothalamic tuberomamillary nucleus,
from where they project to many brain areas. The histaminergic system is involved in basic …

Central effects of fexofenadine and cetirizine: measurement of psychomotor performance, subjective sleepiness, and brain histamine H1‐receptor occupancy using …

M Tashiro, Y Sakurada, K Iwabuchi… - The Journal of …, 2004 - Wiley Online Library
Histamine H1‐receptor (H1R) antagonists, or antihistamines, often induce sedative side
effects when used for the treatment of allergic disorders. This study compared the sedative …

Brain networks of perceptual decision-making: an fMRI ALE meta-analysis

MC Keuken, C Müller-Axt, R Langner… - Frontiers in human …, 2014 - frontiersin.org
In the recent perceptual decision-making literature, a fronto-parietal network is typically
reported to primarily represent the neural substrate of human perceptual decision-making …

Positron emission tomography evaluation of sedative properties of antihistamines

K Yanai, D Zhang, M Tashiro, T Yoshikawa… - Expert opinion on …, 2011 - Taylor & Francis
Introduction: H1 antihistamines are often used in the medication for allergic diseases,
coughs and colds, and insomnia, with or without prescription, even though their sedative …

Over-the-counter medication and herbal or dietary supplement use in college: dose frequency and relationship to self-reported distress

MJ Stasio, K Curry, KM Sutton-Skinner… - Journal of American …, 2008 - Taylor & Francis
Objective: A growing number of researchers have examined the use of over-the-counter
(OTC) medications and herbal or dietary supplements among college students. There is …

Effects of fexofenadine and hydroxyzine on brake reaction time during car‐driving with cellular phone use

M Tashiro, E Horikawa, H Mochizuki… - Human …, 2005 - Wiley Online Library
Antihistamines are a mainstay treatment for allergic rhinitis; however, many older agents
cause adverse events, including sedation and central nervous system (CNS) impairment …

Effects of sedative antidepressants on prefrontal cortex activity during verbal fluency task in healthy subjects: a near-infrared spectroscopy study

K Kohmura, K Iwamoto, B Aleksic, K Sasada… - …, 2013 - Springer
Rationale Japanese researchers have recently conducted studies using near-infrared
spectroscopy (NIRS) to help diagnose psychiatric disorders based on changes in brain …