Although senescence was originally described as an in vitro acquired cellular characteristic,
it was recently recognized that senescence is physiologically and pathologically involved in …

The pathophysiology of vitiligo is complex although recent research has discovered several
markers which are linked to vitiligo and associated with disease activity. Besides providing …

Vitiligo is characterized by progressive loss of skin pigmentation. The search for aetiologic
factors has led to the biochemical, the neurologic and the autoimmune theory. The …

Fibroblasts are crucial components of the skin structure. They were traditionally believed to
maintain the skin's structure by producing extracellular matrix and other elements. Recent …

Vitiligo is a common acquired pigmentary disorder that presents as progressive loss of
melanocytes from the skin. Epidermal melanocytes and keratinocytes are in close proximity …

Vitiligo is a disfiguring depigmentation disorder characterized by loss of melanocytes.
Although numerous studies have been conducted on the pathogenesis of vitiligo, the …

Allergic contact dermatitis (ACD) is caused by topical exposure to chemical allergens.
Keratinocytes play a key role in innate immunity, as well as in ACD progression. The …

Recently, multiple culprits—in addition to melanocytes—have been implicated in the
pathogenesis of vitiligo. Among those factors are fibroblasts. However, their exact role has …

Primary cilia play a significant role in influencing cell fate, including apoptosis in multiple cell
types. In the lesional epidermis of vitiligo patients, a reduced number of ciliated cells was …

Background The current therapies for vitiligo require long duration with often disappointing
outcomes. 5‐Fluorouracil (5‐FU) is a chemotherapeutic agent approved for topical use in …