Post-birth there is a bacterial assault on all mucosal surfaces. The intestinal microbiome is
an important participant in health and disease. The pattern of composition and concentration …

Regulatory T cells (Tregs) are comprised of a heterogeneous population of cells that play a
vital role in suppressing inflammation and maintaining immune tolerance. Given the crucial …

Uterine fibroids (UFs) are the most common benign tumors of the female genital tract. The
incidence of UFs has been estimated at 25–80% depending on selected population. The …

The immune response is a key factor in the fight against HPV infection and related cancers,
and thus, HPV is able to promote immune evasion through the expression of oncogenes. In …

The transcription factor NRF2 is the major mediator of oxidative stress responses and is
closely connected to therapy resistance in tumors harboring activating mutations in the …

Abstract Background Mesenchymal stem cells (MSCs) have shown promising results in
stimulating cartilage repair and in the treatment of osteoarthritis (OA). However, the fate of …

Fatty acids are involved in T cell biology both as nutrients important for energy production as
well as signaling molecules. In particular, polyunsaturated fatty acids are known to exhibit a …

Objective. There is limited information of the anti‐inflammatory effects of Rg3 on inflamed
lung cells and tissues. Therefore, we confirmed the anti‐inflammatory mechanism of …

The transcription factor NRF2 is known as the master regulator of the oxidative stress
response. Tumor entities presenting oncogenic activation of NRF2, such as lung …

Cytotoxic T lymphocytes (CTL) are antigen-specific effector cells with the ability to eradicate
cancer cells in a contact-dependent manner. Metabolic perturbation compromises the CTL …