Although tissue homeostasis—the steady state—implies stability, our organs are in a state of
continual, large-scale cellular flux. This flux underpins an organ's ability to homeostatically …

An active immune response is energetically demanding and requires reallocation of
nutrients to support resistance to and tolerance of infection. Insulin signaling is a critical …

Pharmacological attenuation of mTOR presents a promising route for delay of age-related
disease. Here we show that treatment of Drosophila with the mTOR inhibitor rapamycin …

Nutrient availability is a major selective force in the evolution of metazoa, and thus plasticity
in tissue function and morphology is shaped by adaptive responses to nutrient changes …

Frequent exposure to mechanistic damages, pathological ingression, and chronic
inflammation leads to recurrent cell death in the gut epithelium. Intestinal stem cells (ISCs) …

The insect gut is frequently exposed to pathogenic threats and must not only clear these
potential infections, but also tolerate relatively high microbe loads. In contrast to the …

Background Hematophagous mosquitoes transmit many pathogens that cause human
diseases. Pathogen acquisition and transmission occur when female mosquitoes blood feed …

The adult intestine is a regionalized organ, whose size and cellular composition are
adjusted in response to nutrient status. This involves dynamic regulation of intestinal stem …

Upon exposure to a bacterial pore-forming toxin, enterocytes rapidly purge their apical
cytoplasm into the gut lumen, resulting in a thin intestinal epithelium. The enterocytes regain …

Adult tissues in Metazoa dynamically remodel their structures in response to environmental
challenges including sudden injury, pathogen infection, and nutritional fluctuation, while …