Zinc essentiality, toxicity, and its bacterial bioremediation: A comprehensive insight

S Hussain, M Khan, TMM Sheikh, MZ Mumtaz… - Frontiers in …, 2022 - frontiersin.org
Zinc (Zn) is one of the most abundantly found heavy metals in the Earth's crust and is
reported to be an essential trace metal required for the growth of living beings, with it being a …

Epidemiology and risk factors for IBD

AN Ananthakrishnan - Nature reviews Gastroenterology & hepatology, 2015 - nature.com
IBD, comprising Crohn's disease and ulcerative colitis, is a chronic immunologically
mediated disease at the intersection of complex interactions between genetics, environment …

Pseudomonas aeruginosa transcriptome during human infection

DM Cornforth, JL Dees, CB Ibberson… - Proceedings of the …, 2018 - National Acad Sciences
Laboratory experiments have uncovered many basic aspects of bacterial physiology and
behavior. After the past century of mostly in vitro experiments, we now have detailed …

Unraveling the Underlying Heavy Metal Detoxification Mechanisms of Bacillus Species

BS Alotaibi, M Khan, S Shamim - Microorganisms, 2021 - mdpi.com
The rise of anthropogenic activities has resulted in the increasing release of various
contaminants into the environment, jeopardizing fragile ecosystems in the process. Heavy …

The gut microbiota and its interactions with cardiovascular disease

H Xu, X Wang, W Feng, Q Liu, S Zhou… - Microbial …, 2020 - Wiley Online Library
The intestine is colonized by a considerable community of microorganisms that cohabits
within the host and plays a critical role in maintaining host homeostasis. Recently …

Gut microbiota as a mediator of essential and toxic effects of zinc in the intestines and other tissues

AV Skalny, M Aschner, XG Lei, VA Gritsenko… - International journal of …, 2021 - mdpi.com
The objective of the present study was to review the existing data on the association
between Zn status and characteristics of gut microbiota in various organisms and the …

The ins and outs of bacterial iron metabolism

ER Frawley, FC Fang - Molecular microbiology, 2014 - Wiley Online Library
Iron is a critical nutrient for the growth and survival of most bacterial species. Accordingly,
much attention has been paid to the mechanisms by which host organisms sequester iron …

Type VI Secretion System Transports Zn2+ to Combat Multiple Stresses and Host Immunity

T Wang, M Si, Y Song, W Zhu, F Gao, Y Wang… - PLoS …, 2015 - journals.plos.org
Type VI secretion systems (T6SSs) are widespread multi-component machineries that
translocate effectors into either eukaryotic or prokaryotic cells, for virulence or for …

Membrane anchoring stabilizes and favors secretion of New Delhi metallo-β-lactamase

LJ González, G Bahr, TG Nakashige, EM Nolan… - Nature chemical …, 2016 - nature.com
Abstract Carbapenems,'last-resort'β-lactam antibiotics, are inactivated by zinc-dependent
metallo-β-lactamases (MBLs). The host innate immune response withholds nutrient metal …

Inhibitors of metallo-β-lactamases

CM Rotondo, GD Wright - Current opinion in microbiology, 2017 - Elsevier
The β-lactams are the most successful class of antibiotic drugs but they are vulnerable to
inactivation by a growing cadre of β-lactamases that now number more than a thousand …