Reintroducing fenfluramine as a treatment for seizures: current knowledge, recommendations and gaps in understanding

G Dini, G Di Cara, P Ferrara, P Striano… - … Disease and Treatment, 2023 - Taylor & Francis
Despite the introduction of new anti-seizure medications in recent years, approximately one-
third of the epileptic population continues to experience seizures. Recently, the anti-obesity …

Revisiting the concept of drug‐resistant epilepsy: a TASK1 report of the ILAE/AES Joint Translational Task Force

S Auvin, AS Galanopoulou, SL Moshé, H Potschka… - …, 2023 - Wiley Online Library
Despite progress in the development of anti‐seizure medications (ASMs), one third of
people with epilepsy have drug‐resistant epilepsy (DRE). The working definition of DRE …

[HTML][HTML] The emerging roles of π subunit-containing GABAA receptors in different cancers

IIA Juvale, Z Hassan, ATC Has - International Journal of Medical …, 2021 - ncbi.nlm.nih.gov
Cancer is one of the leading causes of death in both developed and developing countries.
Due to its heterogenous nature, it occurs in various regions of the body and often goes …

Semaglutide attenuates seizure severity and ameliorates cognitive dysfunction by blocking the NLR family pyrin domain containing 3 inflammasome in …

L Wang, J Ding, C Zhu, B Guo… - International …, 2021 - spandidos-publications.com
Epilepsy comorbidities and anti‑epileptic drugs (AEDs) are currently the main limitations of
epilepsy treatment. Semaglutide is a glucagon like peptide‑1 analogue that has entered the …

Synchroextracting chirplet transform-based epileptic seizures detection using EEG

Y Jiang, W Chen, M Li, T Zhang, Y You - Biomedical Signal Processing and …, 2021 - Elsevier
With the development of computer technology, computer-aided medical diagnosis based on
signal processing is trending up. In recent years, the detection of epilepsy …

Current principles in the management of drug-resistant epilepsy

NA Shlobin, JW Sander - CNS drugs, 2022 - Springer
Drug-resistant epilepsy is associated with poor health outcomes and increased economic
burden. In the last three decades, various new antiseizure medications have been …

Integrated macrogenomics and metabolomics explore alterations and correlation between gut microbiota and serum metabolites in adult epileptic patients: a pilot …

K Zhou, L Jia, Z Mao, P Si, C Sun, Z Qu, W Wang - Microorganisms, 2023 - mdpi.com
Epilepsy (EP) is a complex brain disorder showing a lot of unknows reasons. Recent studies
showed that gut microbiota can influence epilepsy via the brain–gut axis. Nevertheless, the …

Drug transport in the brain

V Sangha, EI Williams, PT Ronaldson… - … and role in drug …, 2022 - Wiley Online Library
In the central nervous system (CNS), the effective delivery of pharmacological agents
remains limited by several brain barriers [ie, the blood–brain barrier (BBB), blood …

Blockade of TASK-1 channel improves the efficacy of levetiracetam in chronically epileptic rats

JE Kim, TC Kang - Biomedicines, 2022 - mdpi.com
Tandem of P domains in a weak inwardly rectifying K+ channel (TWIK)-related acid sensitive
K+-1 channel (TASK-1) is an outwardly rectifying K+ channel that acts in response to …

Cannabis medicinal como alternativa terapéutica para la Epilepsia: una revisión sistemática

AO Huayra Alvarez - 2022 - repositorio.ucsm.edu.pe
La epilepsia es una de las enfermedades neurológicas más antiguas y reconocidas del
mundo. En las últimas dos décadas se han utilizado clínicamente varios fármacos …