Management of virologic failure and HIV drug resistance

SM McCluskey, MJ Siedner… - Infectious Disease Clinics, 2019 - id.theclinics.com
In 2014, the Joint United Nations Programme on HIV and AIDS established global targets
such that 90% of people with HIV will be diagnosed, 90% of those diagnosed will be on …

HIV drug resistance in low-income and middle-income countries

RL Hamers, TFR de Wit, CB Holmes - The Lancet HIV, 2018 - thelancet.com
After 15 years of global scale-up of antiretroviral therapy (ART), rising prevalence of HIV
drug resistance in many low-income and middle-income countries (LMICs) poses a growing …

Limited emergence of resistance to integrase strand transfer inhibitors (INSTIs) in ART-experienced participants failing dolutegravir-based antiretroviral therapy: A …

A Abdullahi, IM Kida, UA Maina… - Journal of …, 2023 - academic.oup.com
Background Due to the high prevalence of resistance to NNRTI-based ART since 2018,
consolidated recommendations from the WHO have indicated dolutegravir as the preferred …

Second-line HIV treatment failure in sub-Saharan Africa: A systematic review and meta-analysis

D Edessa, M Sisay, F Asefa - PloS one, 2019 - journals.plos.org
Background Increased second-line antiretroviral therapy (ART) failure rate narrows future
options for HIV/AIDS treatment. It has critical implications in resource-limited settings; …

Curbing the rise of HIV drug resistance in low-income and middle-income countries: the role of dolutegravir-containing regimens

SC Inzaule, RL Hamers, M Doherty… - The Lancet Infectious …, 2019 - thelancet.com
To improve virological suppression and address the emerging threat of HIV drug resistance,
many low-income and middle-income countries are moving away from non-nucleoside …

High HIV prevalence and associated factors in Lesotho: Results from a population-based survey

A Schwitters, S McCracken, K Frederix, R Tierney… - Plos one, 2022 - journals.plos.org
Despite extensive global efforts, sub-Saharan Africa remains disproportionately affected by
the HIV epidemic. This generalized epidemic can be seen in Lesotho which in 2014 the HIV …

Epidemiology of HIV drug resistance in low-and middle-income countries and WHO global strategy to monitor its emergence

S Bertagnolio, MR Jordan, A Giron… - Current Opinion in HIV …, 2022 - journals.lww.com
Epidemiology of HIV drug resistance in low- and middle-incom... : Current Opinion in HIV and
AIDS Epidemiology of HIV drug resistance in low- and middle-income countries and WHO …

[HTML][HTML] Acquired HIV drug resistance mutations on first-line antiretroviral therapy in Southern Africa: Systematic review and Bayesian evidence synthesis

A Hauser, F Goldstein, ML Reichmuth… - Journal of clinical …, 2022 - Elsevier
Objective: To estimate the prevalence of NRTI and NNRTI drug resistance mutations in
patients failing NNRTI-based ART in Southern Africa. Study design: We conducted a …

[HTML][HTML] Switching to coformulated bictegravir, emtricitabine, and tenofovir alafenamide maintained viral suppression in adults with historical virological failures and …

MS Tsai, HY Sun, CP Chen, CH Lee, CY Lee… - International Journal of …, 2023 - Elsevier
Objectives Real-world experience with coformulated bictegravir, emtricitabine, and tenofovir
alafenamide (BIC/FTC/TAF) is sparse as a switch regimen among people living with HIV …

Determining virological suppression and resuppression by point-of-care viral load testing in a HIV care setting in sub-Saharan Africa

G Villa, A Abdullahi, D Owusu, C Smith… - …, 2020 - thelancet.com
Background This prospective pilot study explored same-day point-of-care viral load testing
in a setting in Ghana that has yet to implement virological monitoring of antiretroviral therapy …