Amino acid transporters in cancer and their relevance to “glutamine addiction”: novel targets for the design of a new class of anticancer drugs
Tumor cells have an increased demand for amino acids because of their rapid proliferation
rate. In addition to their need in protein synthesis, several amino acids have other roles in …
rate. In addition to their need in protein synthesis, several amino acids have other roles in …
[HTML][HTML] Reduction–oxidation pathways involved in cancer development: a systematic review of literature reviews
X Gào, B Schöttker - Oncotarget, 2017 - ncbi.nlm.nih.gov
Oxidative stress results from an imbalance of the reactive oxygen species/reactive nitrogen
species (ROS/RNS) production and the oxidants defense system. Extensive research during …
species (ROS/RNS) production and the oxidants defense system. Extensive research during …
Apoptosis induced by luteolin in breast cancer: Mechanistic and therapeutic perspectives
Background Breast cancer is worldwide commonly found malignancy in women and
effective treatment is regarded as a huge clinical challenge even in the presence of several …
effective treatment is regarded as a huge clinical challenge even in the presence of several …
Long non-coding RNAs in cancer drug resistance development
M Majidinia, B Yousefi - DNA repair, 2016 - Elsevier
The presence or emergence of chemoresistance in tumor cells is a major burden in cancer
therapy. While drug resistance is a multifactorial phenomenon arising from altered …
therapy. While drug resistance is a multifactorial phenomenon arising from altered …
The crosstalk between Wnt/β-catenin signaling pathway with DNA damage response and oxidative stress: implications in cancer therapy
DNA repair is essential for maintaining genomic integrity in cells. The dependence of cancer
cell survival on proper DNA repair provides an opportunity to treat defective tumors by DNA …
cell survival on proper DNA repair provides an opportunity to treat defective tumors by DNA …
MicroRNAs and colorectal cancer chemoresistance: New solution for old problem
Background Colorectal cancer (CRC) is one of the most common gastrointestinal
malignancies with a significant mortality rate. Despite the great advances in cancer …
malignancies with a significant mortality rate. Despite the great advances in cancer …
DNA repair and damage pathways in breast cancer development and therapy
M Majidinia, B Yousefi - DNA repair, 2017 - Elsevier
DNA damage/repair constitutes several key pathways working in concert to eliminate DNA
lesions and maintain genome stability and integrity. Defective components in DNA damage …
lesions and maintain genome stability and integrity. Defective components in DNA damage …
Regulation of thymidylate synthase: an approach to overcome 5-FU resistance in colorectal cancer
Thymidylate synthase is the rate-limiting enzyme required for DNA synthesis and
overexpression of this enzyme causes resistance to cancer cells. Long treatments with 5-FU …
overexpression of this enzyme causes resistance to cancer cells. Long treatments with 5-FU …
The oncogenic roles of bacterial infections in development of cancer
Initiation of cancer is interconnected with different factors like infections. It has been
estimated that infections, particularly viruses, participate in about 20% of all cancers …
estimated that infections, particularly viruses, participate in about 20% of all cancers …
Crosstalk between Phosphoinositide 3‐kinase/Akt signaling pathway with DNA damage response and oxidative stress in cancer
Abstract The phosphatidylinositol 3‐kinases (PI3K)/Akt signaling pathway is one of the well‐
characterized and most important signaling pathways activated in response to DNA …
characterized and most important signaling pathways activated in response to DNA …