Background: The G protein-coupled receptor 55 (GPR55) is a mammalian orphan receptor
that awaits a formal classification. There are an increasing number of reports directed to …

Background: Marijuana extracts (cannabinoids) have been used for several millennia for
pain treatment. Regarding the site of action, cannabinoids are highly promiscuous …

Lysophosphatidylinositols (LPIs) are membrane constituents that alter the properties of said
membranes. However, recent data showing that the once orphan receptor, GPR55, can act …

GPR55 is a class A orphan G protein-coupled receptor that has drawn important therapeutic
attention in the last decade because of its role in pathophysiological processes including …

A large number of cannabinoids have been discovered that could play a role in mitigating
cardiac affections. However, none of them has been as widely studied as cannabidiol …

The periaqueductal gray (PAG) is a complex mesencephalic structure involved in the
integration and execution of active and passive self-protective behaviors against imminent …

Endocannabinoids are ancient biomolecules involved in several cellular (eg, metabolism)
and physiological (eg, eating behaviour) functions. Indeed, eating behaviour alterations in …

Endocannabinoids (eCBs) are involved in the hippocampal mechanisms of spatial learning
and memory in rats. Although eCBs exert many of their actions on spatial learning and …

Cannabinoids are known to modulate cardiovascular functions including heart rate, vascular
tone, and blood pressure in humans and animal models. Essential components of the …

GPR12 is a G protein-coupled orphan receptor genetically related to type 1 and type 2
cannabinoid receptors (CB1 and CB2) which are ancient proteins expressed all over the …