Role of glutamate excitotoxicity and glutamate transporter EAAT2 in epilepsy: Opportunities for novel therapeutics development

JL Green, WF Dos Santos, ACK Fontana - Biochemical pharmacology, 2021 - Elsevier
Epilepsy is a complex neurological syndrome characterized by seizures resulting from
neuronal hyperexcitability and sudden and synchronized bursts of electrical discharges …

Neurobiology, functions, and relevance of excitatory amino acid transporters (EAATs) to treatment of refractory epilepsy

AV Zaitsev, IV Smolensky, P Jorratt, SV Ovsepian - CNS drugs, 2020 - Springer
Epilepsy is one of the most prevalent and devastating neurological disorders characterized
by episodes of unusual sensations, loss of awareness, and reoccurring seizures. The …

Omega-3 fatty acids prevent nicotine withdrawal-induced impairment of learning and memory via affecting oxidative status, inflammatory response, cholinergic activity …

SM Ahmadi-Soleimani, GY Amiry, E Khordad… - Life Sciences, 2023 - Elsevier
In the present study, the main objective was to reveal whether treatment by Omega-3 fatty
acids could prevent the adverse effects of adolescent nicotine withdrawal on spatial and …

Nrf2 is predominantly expressed in hippocampal neurons in a rat model of temporal lobe epilepsy

S Sandouka, A Saadi, PK Singh, R Olowe… - Cell & Bioscience, 2023 - Springer
Background Drug resistance is a particular problem in patients with temporal lobe epilepsy,
where seizures originate mainly from the hippocampus. Many of these epilepsies are …

Maternal hyperhomocysteinemia produces memory deficits associated with impairment of long-term synaptic plasticity in young rats

TY Postnikova, DV Amakhin, AM Trofimova… - Cells, 2022 - mdpi.com
Maternal hyperhomocysteinemia (HCY) is a common pregnancy complication caused by
high levels of the homocysteine in maternal and fetal blood, which leads to the alterations of …

Prenatal hyperhomocysteinemia induces glial activation and alters neuroinflammatory marker expression in infant rat hippocampus

AD Shcherbitskaia, DS Vasilev, YP Milyutina… - Cells, 2021 - mdpi.com
Maternal hyperhomocysteinemia is one of the common complications of pregnancy that
causes offspring cognitive deficits during postnatal development. In this study, we …

Maternal hyperhomocysteinemia disturbs the mechanisms of embryonic brain development and its maturation in early postnatal ontogenesis

DS Vasilev, AD Shcherbitskaia, NL Tumanova… - Cells, 2023 - mdpi.com
Maternal hyperhomocysteinemia causes the disruption of placental blood flow and can lead
to serious disturbances in the formation of the offspring's brain. In the present study, the …

[HTML][HTML] Polysaccharide-rich extract of Genipa americana leaves protects seizures and oxidative stress in the mice model of pentylenetetrazole-induced epilepsy

DTT Nonato, GF Aragão, RMCB Craveiro… - Biomedicine & …, 2024 - Elsevier
Plant polysaccharides have biological activities in the brain and those obtained from Genipa
americana leaves present antioxidant and anticonvulsant effects in the mice model of …

Ferulic acid ameliorates pentylenetetrazol-induced seizures by reducing neuron cell death

SH Zhang, D Liu, Q Hu, J Zhu, S Wang, S Zhou - Epilepsy Research, 2019 - Elsevier
To investigate the neuroprotective effect of ferulic acid (FA) in a pentylenetetrazol (PTZ)-
induced seizures model in rat, the motor response, spatial learning ability and memory …

Alterations in mRNA expression of glutamate receptor subunits and excitatory amino acid transporters following pilocarpine-induced seizures in rats

OE Zubareva, AA Kovalenko, SV Kalemenev… - Neuroscience …, 2018 - Elsevier
Temporal lobe epilepsy is the most prevalent form of complex partial seizure, and it is
frequently triggered by an initial brain-damaging insult. The prevention of epileptogenesis …