High-throughput technologies have revolutionized medical research. The advent of
genotyping arrays enabled large-scale genome-wide association studies and methods for …

Multiple recent studies highlight that genetic variants can have strong impacts on a
significant proportion of the human DNA methylome. Methylation quantitative trait loci, or …

Recent research efforts provided compelling evidence of genome-wide DNA methylation
alterations in aging and age-related disease. It is currently well established that DNA …

Atherosclerosis is classed as a disease of aging, such that increasing age is an independent
risk factor for the development of atherosclerosis. Atherosclerosis is also associated with …

Background: Recent technological advances in epigenome profiling have led to an
increasing number of studies investigating the role of the epigenome in obesity. There is …

Molecularly imprinted polymers (MIPs) are the equivalent of natural antibodies and have
been widely used as synthetic receptors for the detection of disease biomarkers. Benefiting …

Biomarkers are naturally-occurring characteristics by which a particular pathological process
or disease can be identified or monitored. They can reflect past environmental exposures …

Background: DNA methylation is implicated in coronary heart disease (CHD), but current
evidence is based on small, cross-sectional studies. We examined blood DNA methylation …

Background Cardiovascular disease (CVD) is the leading cause of death worldwide and
considered one of the most environmentally driven diseases. The role of DNA methylation in …

Nutritional factors play a life-long role in human health. Indeed, there is growing evidence
that one of the mechanisms by which nutrients and bioactive compounds affect metabolic …