Malarial hemozoin: from target to tool

LM Coronado, CT Nadovich, C Spadafora - Biochimica et Biophysica Acta …, 2014 - Elsevier
Background Malaria is an extremely devastating disease that continues to affect millions of
people each year. A distinctive attribute of malaria infected red blood cells is the presence of …

Antimalarial application of quinones: A recent update

OPS Patel, RM Beteck, LJ Legoabe - European Journal of Medicinal …, 2021 - Elsevier
Atovaquone belongs to a naphthoquinone class of drugs and is used in combination with
proguanil (Malarone) for the treatment of acute, uncomplicated malaria caused by …

CYP2B6 functional variability in drug metabolism and exposure across populations—implication for drug safety, dosing, and individualized therapy

IM Langmia, KS Just, S Yamoune, J Brockmöller… - Frontiers in …, 2021 - frontiersin.org
Adverse drug reactions (ADRs) are one of the major causes of morbidity and mortality
worldwide. It is well-known that individual genetic make-up is one of the causative factors of …

Evidence for the early emergence of piperaquine-resistant Plasmodium falciparum malaria and modeling strategies to mitigate resistance

JL Small-Saunders, LM Hagenah, KJ Wicht… - PLoS …, 2022 - journals.plos.org
Multidrug-resistant Plasmodium falciparum parasites have emerged in Cambodia and
neighboring countries in Southeast Asia, compromising the efficacy of first-line antimalarial …

Artemisinin-based combination therapy for uncomplicated Plasmodium falciparum malaria in Mali: a systematic review and meta-analysis

FO Maiga, M Wele, SM Toure, M Keita, CO Tangara… - Malaria Journal, 2021 - Springer
Background Artemisinin-based combination therapy (ACT) was deployed in 2005 as an
alternative to chloroquine and is considered the most efficacious treatment currently …

[HTML][HTML] A literature review on traditional herbal medicines for malaria

M Noronha, V Pawar, A Prajapati… - South African Journal of …, 2020 - Elsevier
Malaria is known to cause around 1 million deaths per annum. This life-threatening disease
is mostly prevalent in Africa. Due to the burgeoning problem of drug resistance, it is getting …

[HTML][HTML] Zwitterionic self-assembled nanoparticles as carriers for Plasmodium targeting in malaria oral treatment

A Biosca, P Cabanach, M Abdulkarim… - Journal of Controlled …, 2021 - Elsevier
The current decline in antimalarial drug efficacy due to the evolution of resistant Plasmodium
strains calls for new strategies capable of improving the bioavailability of antimalarials …

Role of Different Pfcrt and Pfmdr‐1 Mutations in Conferring Resistance to Antimalaria Drugs in Plasmodium falciparum

ZO Ibraheem, R Abd Majid, SM Noor… - Malaria research …, 2014 - Wiley Online Library
Emergence of drugs resistant strains of Plasmodium falciparum has augmented the scourge
of malaria in endemic areas. Antimalaria drugs act on different intracellular targets. The …

Antiplasmodial activity of extracts of Tridax procumbens and Phyllanthus amarus in in vitro Plasmodium falciparum culture systems

R Appiah-Opong, AK Nyarko, D Dodoo, FN Gyang… - Ghana Medical …, 2011 - ajol.info
Background: Aqueous extracts of Tridax procumbens (TP)(Compositae) and Phyllanthus
amarus (PA)(Euphorbiaceae) are used in traditional medicine in Ghana to treat malaria …

Bibliometric analysis of worldwide publications on antimalarial drug resistance (2006–2015)

WM Sweileh, SW Al-Jabi, AF Sawalha… - Malaria research …, 2017 - Wiley Online Library
Background. In response to international efforts to control and eradicate malaria, we
designed this study to give a bibliometric overview of research productivity in antimalarial …