Regulation of adult stem cell quiescence and its functions in the maintenance of tissue integrity

A de Morree, TA Rando - Nature Reviews Molecular Cell Biology, 2023 - nature.com
Adult stem cells are important for mammalian tissues, where they act as a cell reserve that
supports normal tissue turnover and can mount a regenerative response following acute …

Quiescence of adult mammalian neural stem cells: a highly regulated rest

N Urbán, IM Blomfield, F Guillemot - Neuron, 2019 - cell.com
Neural stem cells in the adult mammalian brain are the source of new neurons that
contribute to complex sensory and cognitive functions. Most adult neural stem cells are …

Neurogenesis in the embryonic and adult brain: same regulators, different roles

N Urbán, F Guillemot - Frontiers in cellular neuroscience, 2014 - frontiersin.org
Neurogenesis persists in adult mammals in specific brain areas, known as neurogenic
niches. Adult neurogenesis is highly dynamic and is modulated by multiple physiological …

Stem cell quiescence: the challenging path to activation

N Urbán, TH Cheung - Development, 2021 - journals.biologists.com
Quiescence is a cellular state in which a cell remains out of the cell cycle but retains the
capacity to divide. The unique ability of adult stem cells to maintain quiescence is crucial for …

Cell cycle arrest determines adult neural stem cell ontogeny by an embryonic Notch-nonoscillatory Hey1 module

Y Harada, M Yamada, I Imayoshi, R Kageyama… - Nature …, 2021 - nature.com
Quiescent neural stem cells (NSCs) in the adult mouse brain are the source of neurogenesis
that regulates innate and adaptive behaviors. Adult NSCs in the subventricular zone are …

LRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells

MÁ Marqués-Torrejón, CAC Williams… - Nature …, 2021 - nature.com
Adult neural stem cells (NSCs) must tightly regulate quiescence and proliferation. Single-cell
analysis has suggested a continuum of cell states as NSCs exit quiescence. Here we …

Ontogeny of adult neural stem cells in the mammalian brain

AM Bond, G Ming, H Song - Current topics in developmental biology, 2021 - Elsevier
Neural stem cells (NSCs) persist into adulthood in the subgranular zone (SGZ) of the
dentate gyrus in the hippocampus and in the ventricular-subventricular zone (V-SVZ) of the …

Adult neural stem cells: born to last

AV Morales, H Mira - Frontiers in Cell and Developmental Biology, 2019 - frontiersin.org
The generation of new neurons is a lifelong process in many vertebrate species that
provides an extra level of plasticity to several brain circuits. Frequently, neurogenesis in the …

Detection and phenotypic characterization of adult neurogenesis

HG Kuhn, AJ Eisch, K Spalding… - Cold Spring Harbor …, 2016 - cshperspectives.cshlp.org
Studies of adult neurogenesis have greatly expanded in the last decade, largely as a result
of improved tools for detecting and quantifying neurogenesis. In this review, we summarize …

Waking up quiescent neural stem cells: molecular mechanisms and implications in neurodevelopmental disorders

WY Ding, J Huang, H Wang - PLoS genetics, 2020 - journals.plos.org
Neural stem cells (NSCs) are crucial for development, regeneration, and repair of the
nervous system. Most NSCs in mammalian adult brains are quiescent, but in response to …