Inflammation: a target for treatment in spinal cord injury

X Freyermuth-Trujillo, JJ Segura-Uribe… - Cells, 2022 - mdpi.com
Spinal cord injury (SCI) is a significant cause of disability, and treatment alternatives that
generate beneficial outcomes and have no side effects are urgently needed. SCI may be …

A comprehensive look at the psychoneuroimmunoendocrinology of spinal cord injury and its progression: mechanisms and clinical opportunities

MA Ortega, O Fraile-Martinez, C García-Montero… - Military Medical …, 2023 - Springer
Spinal cord injury (SCI) is a devastating and disabling medical condition generally caused
by a traumatic event (primary injury). This initial trauma is accompanied by a set of biological …

Microglia coordinate cellular interactions during spinal cord repair in mice

FH Brennan, Y Li, C Wang, A Ma, Q Guo, Y Li… - Nature …, 2022 - nature.com
Traumatic spinal cord injury (SCI) triggers a neuro-inflammatory response dominated by
tissue-resident microglia and monocyte derived macrophages (MDMs). Since activated …

Neuroimmunological therapies for treating spinal cord injury: Evidence and future perspectives

JCT Chio, KJ Xu, P Popovich, S David… - Experimental …, 2021 - Elsevier
Spinal cord injury (SCI) has a complex pathophysiology. Following the initial physical
trauma to the spinal cord, which may cause vascular disruption, hemorrhage, mechanical …

Immune response after central nervous system injury

AFM Salvador, J Kipnis - Seminars in immunology, 2022 - Elsevier
Traumatic injuries of the central nervous system (CNS) affect millions of people worldwide,
and they can lead to severely damaging consequences such as permanent disability and …

The spinal cord injury-induced immune deficiency syndrome: results of the SCIentinel study

MA Kopp, C Meisel, T Liebscher, R Watzlawick… - Brain, 2023 - academic.oup.com
Infections are prevalent after spinal cord injury (SCI), constitute the main cause of death and
are a rehabilitation confounder associated with impaired recovery. We hypothesize that SCI …

Immune dysfunction after spinal cord injury–A review of autonomic and neuroendocrine mechanisms

KA Rodgers, KA Kigerl, JM Schwab… - Current opinion in …, 2022 - Elsevier
Infections impair neurological outcome and increase mortality after spinal cord injury (SCI).
Emerging data show that pathogens more easily infect individuals with SCI because SCI …

Beyond the urothelium: Interplay between autonomic nervous system and bladder inflammation in urinary tract infection, bladder pain syndrome with interstitial cystitis …

M Wyndaele, A Charrua, F Hervé… - Neurourology and …, 2024 - Wiley Online Library
Introduction Inflammation and neuronal hypersensitivity are reactive protective mechanisms
after urothelial injury. In lower urinary tract dysfunctions (LUTD), such as urinary tract …

Peripheral immune dysfunction: a problem of central importance after spinal cord injury

MA Jeffries, VJ Tom - Biology, 2021 - mdpi.com
Simple Summary Spinal cord injury can result in an increased vulnerability to infections, but
until recently the biological mechanisms behind this observation were not well defined …

Re-directing nanomedicines to the spleen: A potential technology for peripheral immunomodulation

S Kaur, SM Allan, ZS Al-Ahmady - Journal of Controlled Release, 2022 - Elsevier
Modulation of peripheral immune cells in the spleen plays a key role in many life-threatening
conditions such as stroke. Immune cell changes can lead to the excessive release of pro …