Drug resistance is a major obstacle in the field of pre-clinical and clinical therapeutics. The
development of novel technologies and targeted therapies have yielded new modalities to …

Over the past ten years, proteasome inhibition has emerged as an effective therapeutic
strategy for treating multiple myeloma (MM) and some lymphomas. In 2003, Bortezomib …

Using a combination of computer methods for iterative database searches and multiple
sequence alignment, we show that protein sequences related to the AAA family of ATPases …

For a number of years, poultry selection has concentrated on growth velocity in meat lines,
producing improvements in growth that have not been without consequence for muscle …

PURPOSE: To determine the maximum-tolerated dose (MTD), dose-limiting toxicity (DLT),
and pharmacodynamics (PD) of the proteasome inhibitor bortezomib (previously known as …

Cancer cells are characterized by a higher rate of protein turnover and greater demand for
protein homeostasis compared to normal cells. In this scenario, the ubiquitin–proteasome …

This text presents contemporary analytical techniques for the determination of heavy metals
in air particles, water, soil and biological samples. It details experimental studies to reduce …

The cellular process of autophagy (literally “self-eating”) is important for maintaining the
homeostasis and bioenergetics of mammalian cells. Two of the best-studied mechanisms of …

The proteasome is a multicatalytic proteinase complex responsible for the degradation of
most intracellular proteins, including proteins crucial to cell cycle regulation and …

Coordinated intracellular protein degradation mediated by the ubiquitin-proteasome
pathway is crucial to a vast array of cellular processes including orderly progression through …