In cancer, the overall patterns of epigenetic marks are severely distorted from the
corresponding normal cell type. It is now well established that these changes can contribute …

DNA repair represents the first barrier against genotoxic stress causing metabolic changes,
inflammation and cancer. Besides its role in preventing cancer, DNA repair needs also to be …

Although soy phytoestrogens have been postulated to exert a protective effect against breast
cancer, the attendant mechanisms, in particular epigenetics underpinnings, have remained …

Purpose: Some 85% of lung cancers are smoking related. Here, we investigate the role of
serine protease HtrA3 in smoking-related lung cancer. Experimental Design: We assess …

S-Equol is a metabolite resulting from the conversion of daidzein, a soya phyto-oestrogen,
by the gut microflora. The potential protective effects of equol in breast cancer are still under …

Dysregulation of homologous recombination (HR) DNA repair has been implicated in breast
carcinogenesis and chemosensitivity. Here, we investigated the methylation status of sixteen …

Background-Sporadic breast cancer like many other cancers is proposed to be a
manifestation of abnormal genetic and epigenetic changes. For the past decade our …

The dissection of the molecular pathways participating in genetic instability disorders has
rendered invaluable information about the mechanisms of cancer pathogenesis and …

Dietary supplementation with folic acid (FA) has been shown to induce opposing effects on
cancer-related outcomes. The mechanism underlying such heterogeneity is unclear. We …

Introduction Giant fibroadenoma is an uncommon variant of benign breast lesions. Aberrant
methylation of CpG islands in promoter regions is known to be involved in the silencing of …