Most antibiotic resistance mechanisms are associated with a fitness cost that is typically
observed as a reduced bacterial growth rate. The magnitude of this cost is the main …

By exploiting the ability of Pseudomonas aeruginosa to infect a variety of vertebrate and
nonvertebrate hosts, we have developed model systems that use plants and nematodes as …

Infection of vertebrate hosts with pathogenic Mycobacteria, the agents of tuberculosis,
produces granulomas, highly organized structures containing differentiated macrophages …

We demonstrate the use of the nematode Caenorhabditis elegans as a facile and
inexpensive model host for several Gram-positive human bacterial pathogens. Enterococcus …

The opportunistic human pathogen Pseudomonas aeruginosa causes persistent airway
infections in patients with cystic fibrosis (CF). To establish these chronic infections, P …

Background: Both animals and plants respond rapidly to pathogens by inducing the
expression of defense-related genes. Whether such an inducible system of innate immunity …

The human opportunistic pathogen Serratia marcescens is a bacterium with a broad host
range, and represents a growing problem for public health. Serratia marcescens kills …

Due to its small size, rapid generation time, powerful genetic systems, and genomic
resources, the zebrafish has emerged as an important model of vertebrate development and …

The genome of Pseudomonas aeruginosa PAO1 contains three type VI secretion systems
(T6SSs) called H1-, H2-, and H3-T6SS. The H1-T6SS secretes three identified toxins that …

Insects defend themselves against infectious microorganisms by synthesizing potent
antimicrobial peptides. Drosophila has appeared in recent years as a favorable model to …