Integrated approaches using different in vitro methods in combination with bioinformatics
can (i) increase the success rate and speed of drug development;(ii) improve the accuracy of …

Given the high biological impact of classical and emerging toxicants, a sensitive and
comprehensive assessment of the hazards and risks of these substances to organisms is …

Our previous studies showed that MYB is required for proliferation of, and confers protection
against apoptosis on, estrogen receptor-positive (ER+ ve) breast cancer cells, which are …

Drug induced liver injury (DILI) is an idiosyncratic adverse drug reaction leading to severe
liver damage. Kupffer cells (KC) sense hepatic tissue stress/damage and therefore could be …

Chronic repeated‐dose toxicity studies are still carried out on animals and often do not
correlate with the effects in human beings mainly due to species‐specific differences in …

Since the publication of REACH guidelines, the need for in vitro tools for toxicity testing has
increased. We present here the development of a hepatotoxicity testing tool using human …

Many categories of drugs can induce hepatotoxicity, so improving the prediction of toxic
drugs is important. In vitro models using human hepatocytes are more accurate than in vivo …

Drug-induced liver injury is the most frequent reason for market withdrawal of approved
drugs, and is difficult to predict in animal models. Here, we analyzed transcriptomic data …

Accurate prediction of the potential hepatotoxic nature of new pharmaceuticals remains
highly challenging. Therefore, novel in vitro models with improved external validity are …

Since drug induced liver injury is difficult to predict in animal models, more representative
tests are needed to better evaluate these effects in humans. Existing in vitro systems hold …