Background The remarkable growth of genome-wide association studies (GWAS) has
created a critical need to experimentally validate the disease-associated variants, 90% of …

The clustered regularly interspaced short palindromic repeats (CRISPR)‐based genetic
screening has been demonstrated as a powerful approach for unbiased functional genomics …

The majority of variants associated with complex traits and common diseases identified by
genome-wide association studies (GWAS) map to noncoding regions of the genome with …

Expression quantitative trait locus detection has become increasingly important for
understanding how noncoding variants contribute to disease susceptibility and complex …

Genome-wide association studies (GWAS) have identified numerous genetic loci underlying
human diseases, but a fundamental challenge remains to accurately identify the underlying …

The past 2 decades have witnessed extraordinary advances in our understanding of the
genetic factors influencing inflammatory bowel disease (IBD), providing a foundation for the …

The majority of genetic variants affecting complex traits map to regulatory regions of genes,
and typically lie in credible intervals of 100 or more SNPs. Fine mapping of the causal …

The vast majority of genetic loci associated with polygenic complex traits are located in non-
coding regions of the human genome. However, many of these regions exhibit high-order …

Recent advances in single‐cell transcriptomics and epigenomics technologies open new
avenues to dissect cell heterogeneity in multiple biological processes and identify novel …

CRISPR/Cas9 systems are designed to make site-and sequence-specific alterations to the
genomes of a wide variety of organisms by targeting with user-defined guide RNAs (gRNAs) …