Oncolytic virotherapy is an emerging treatment modality that uses replication-competent
viruses to destroy cancers. Recent advances include preclinical proof of feasibility for a …

Despite advances in treatment, cancer remains a leading cause of death worldwide.
Although treatment strategies are continually progressing, cancers have evolved many …

Cancer immunotherapy and the emergence of immune checkpoint inhibitors have markedly
changed the treatment paradigm for many cancers. They function to disrupt cancer cell …

Oncolytic virus (OV) therapy is an emerging anti-cancer approach that utilizes viruses to
preferentially infect and kill cancer cells, while not harming healthy cells. Vesicular stomatitis …

Natural killer (NK) cells are innate cytotoxic lymphocytes involved in the surveillance and
elimination of cancer. As we have learned more and more about the mechanisms NK cells …

Oncolytic viruses (OVs) are an emerging class of targeted anticancer therapies designed to
selectively infect, replicate in, and lyse malignant cells without causing harm to normal …

Oncolytic viruses (OVs) are highly immunogenic and this limits their use in immune-
competent hosts. Although immunosuppression may improve viral oncolysis, this gain is …

The role of the immune response to oncolytic Herpes simplex viral (oHSV) therapy for
glioblastoma is controversial because it might enhance or inhibit efficacy. We found that …

Intratumoral innate immunity can play a significant role in blocking the effective therapeutic
spread of a number of oncolytic viruses (OVs). Histone deacetylase inhibitors (HDIs) are …

Modern oncotherapy approaches are based on inducing controlled apoptosis in tumor cells.
Although a number of apoptosis-induction approaches are available, site-specific delivery of …